Photo by Ryan Coleman

Find hotels in Sikeston, MO from AED 225

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
1 Nov - 2 Nov
Tomorrow
2 Nov - 3 Nov
Next weekend
7 Nov - 9 Nov
In two weeks
14 Nov - 16 Nov

Filter by

Guest rating
Guest rating
Star rating

Compare 279 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Property amenity
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3.0 star property
9.4 out of 10, Exceptional, (1001)
"Great staff. "
United States
Troy
The price is AED 345
AED 397 total
includes taxes & fees
9 Nov - 10 Nov
Drury Inn & Suites Sikeston, MO
Exterior
Hampton Inn Sikeston
Hampton Inn Sikeston
2.5 star property
8.8 out of 10, Excellent, (416)
"Nice property and friendly staff."
United States
Nancy
The price is AED 358
AED 406 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn Sikeston
Lobby
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 star property
9.4 out of 10, Exceptional, (1002)
"Everything was up to par. Enjoyed our stay. "
United States
Greg
The price is AED 283
AED 325 total
includes taxes & fees
9 Nov - 10 Nov
Pear Tree Inn Sikeston
1 bedroom, desk, laptop workspace, blackout drapes
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2.0 star property
7.2 out of 10, Good, (1003)
"Clean and comfortable "
United States
Jim
The price is AED 231
AED 263 total
includes taxes & fees
11 Nov - 12 Nov
Days Inn and Suites by Wyndham Sikeston
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
8.4 out of 10, Very Good, (701)
"So nice and quiet. Very relaxing "
United States
Lana
The price is AED 207
AED 236 total
includes taxes & fees
2 Nov - 3 Nov
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Free daily full breakfast
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 star property
8.4 out of 10, Very Good, (1015)
"Very convenient and great breakfast "
United States
Duwaine
The price is AED 309
AED 352 total
includes taxes & fees
9 Nov - 10 Nov
Best Western Plus Sikeston
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
8.6 out of 10, Excellent, (435)
"staff was friendly nothing to crazy about this hotel "
United States
Isaac
The price is AED 371
AED 420 total
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express & Suites Sikeston Southwest by IHG
Bar (on property)
Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
9.2 out of 10, Wonderful, (28)
"Nice hotel "
United States
April
The price is AED 371
AED 420 total
includes taxes & fees
9 Nov - 10 Nov
Fairfield Inn & Suites by Marriott Sikeston
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
6.6 out of 10, (558)
"I enjoyed our stay"
United States
Alex
The price is AED 230
AED 262 total
includes taxes & fees
2 Dec - 3 Dec
Super 8 by Wyndham Sikeston/Miner Area
Lobby
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO
3.0 star property
9.6 out of 10, Exceptional, (1009)
"Great service! Definitely will stay there again!"
United States
David
The price is AED 331
AED 349 total
includes taxes & fees
6 Nov - 7 Nov
Drury Inn & Suites Jackson MO
Iron/ironing board, free WiFi, bed sheets
Country Yard Inn and Suite
Country Yard Inn and Suite
2.0 star property
6.8 out of 10, (112)
"Property is a little old. Needs some improvements. "
United States
Dean
The price is AED 196
AED 234 total
includes taxes & fees
2 Nov - 3 Nov
Country Yard Inn and Suite
Exterior
Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
2.5 star property
8.4 out of 10, Very Good, (274)
"It was a very nice stay. The pool was clean and enjoying!"
United States
Lisa
The price is AED 325
AED 370 total
includes taxes & fees
6 Nov - 7 Nov
Comfort Inn & Suites Sikeston I-55
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
8.8 out of 10, Excellent, (644)
"Stayed on our way south for vacation. It was a clean nice place to stay. "
United States
Joel
The price is AED 309
AED 335 total
includes taxes & fees
3 Nov - 4 Nov
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 star property
9.0 out of 10, Wonderful, (1004)
"Everything was clean and looked newly renovated. Staff was friendly. Parking was convenient and the area seemed safe. "
United States
Lisa
The price is AED 257
AED 290 total
includes taxes & fees
2 Nov - 3 Nov
Pear Tree Inn Cape Girardeau West
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
9.6 out of 10, Exceptional, (1001)
"Great place"
United States
Eric
The price is AED 345
AED 389 total
includes taxes & fees
14 Nov - 15 Nov
Drury Plaza Hotel Cape Girardeau Conference Center
Business center
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
3.0 star property
9.4 out of 10, Exceptional, (1003)
"Excellent place. Really friendly staff"
United States
Alex
The price is AED 331
AED 373 total
includes taxes & fees
9 Nov - 10 Nov
Drury Inn & Suites Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
9.0 out of 10, Wonderful, (1004)
"Always enjoy our stay. Staff is very friendly, especially at breakfast! "
United States
Paul
The price is AED 257
AED 290 total
includes taxes & fees
5 Nov - 6 Nov
Pear Tree Inn Cape Girardeau Near the Medical Center
Bar (on property)
TownePlace Suites by Marriott Sikeston
TownePlace Suites by Marriott Sikeston
3.0 star property
8.4 out of 10, Very Good, (5)
"I loved all of what this property had to offer "
United States
Christian
The price is AED 444
AED 503 total
includes taxes & fees
9 Nov - 10 Nov
TownePlace Suites by Marriott Sikeston
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
9.4 out of 10, Exceptional, (1001)
"Clean and welcoming. Tyler at the front desk for check in was engaging and friendly. He’s a gem!!"
United States
Penny
The price is AED 364
AED 410 total
includes taxes & fees
9 Nov - 10 Nov
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Front of property - evening/night
Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
6.6 out of 10, (602)
"Tracey Allen checked me in. She was great!"
United States
Timothy
The price is AED 203
AED 225 total
includes taxes & fees
3 Nov - 4 Nov
Super 8 by Wyndham Charleston/Sikeston East MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Sikeston attractions

City of Miner Convention Center

This versatile 16,000-square-foot venue in Miner, Missouri hosts conferences, weddings, and community gatherings. Modern meeting rooms and a commercial kitchen make it ideal for various events.
See properties

Sikeston Depot Museum

3.8/5 (33 reviews)
Housed in a restored 1916 train depot, this museum showcases Sikeston's cotton-growing heritage and local art. Explore regional history through rotating exhibits while admiring the building's National Register status.
See properties

Sikeston and related destinations

Home to Lambert's Café, the 'Home of Throwed Rolls,' where servers toss fresh bread across the room to hungry diners. Visit the historic Sikeston Depot or catch the annual rodeo where professional cowboys compete in thrilling events each August.

See all hotels in Sikeston
The best restaurant I have EVER been to! Hands down!!!
Photo by Ryan Coleman
Open Photo by Ryan Coleman

Top Sikeston Hotel Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent
"Overall had a comfortable stay. Safe and convenient location. Free breakfast buffet was good, clean. Toaster was not working during our stay, but other than that, was ok. "
Bethany 4-night trip
Posted 2 days ago
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

More cheap stays in Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr, Sikeston, MO
The price is AED 231 per night from Nov 11 to Nov 12
AED 231
AED 263 total
11 Nov - 12 Nov
includes taxes & fees
7.2/10 Good! (1,003 reviews)

Hotels in Sikeston with star-rating

Frequently asked questions

Where is the best place to stay in Sikeston?
Drury Inn & Suites Sikeston, MO is ranked highly by Expedia customers. This hotel offers free breakfast and an outdoor pool. Other top choices based on reviews include Pear Tree Inn Sikeston and Fairfield Inn & Suites by Marriott Sikeston. See all available top hotels, or vacation rentals in Sikeston.
What are some of the best vacation rentals in Sikeston?
Notting Hill Cottage: This vacation home rental outside of Sikeston offers a patio, a private yard, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You and your friends and family can relax into your vacation with amenities like a hot tub. See all vacation rentals in Sikeston.
If I need to cancel my hotel reservation in Sikeston, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Sikeston.
Where can I learn more about changing or cancelling my trip to Sikeston?
For more details about changing or cancelling your trip to Sikeston, head over to our customer service page.
What's the best budget-friendly hotel in Sikeston?
Based on reviews, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) is a popular hotel for our travelers who want a more economical choice, and features free breakfast and free WiFi. View all budget hotels in Sikeston.
What's the best hotel for a family vacation in Sikeston?
Drury Inn & Suites Sikeston, MO is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Pear Tree Inn Sikeston is another good choice for your stay with the kids. Find more child-friendly accommodations in Sikeston.
What is the top LGBTQ-friendly hotel in Sikeston?
Drury Inn & Suites Sikeston, MO is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Pear Tree Inn Sikeston and Hampton Inn Sikeston are two other good options for your vacation.
What's the best pet-friendly accommodation in Sikeston?
Drury Inn & Suites Sikeston, MO is a top hotel for people traveling with their pets, and offers an indoor pool and free WiFi for its human guests. Other good options for you and your pet's trip include Pear Tree Inn Sikeston and Best Western Plus Sikeston. See more pet-friendly hotel accommodations in Sikeston.
Where is the best hotel to stay close to Central Park?
Hampton Inn Sikeston is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located just a short 1 mi (1.6 km) from Central Park. Another good option is Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel, located just 0.9 mi (1.5 km) away.
What about the best place to stay close to Sikeston Depot Museum?
One of the top choices for your stay is Pear Tree Inn Sikeston, located 3.1 mi (5 km) from Sikeston Depot Museum, and this hotel offers free breakfast and an outdoor pool. Hampton Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel are two other good options within a few miles.
What are some accommodations with pools in Sikeston?
Best Western Plus Sikeston is a top hotel with a pool, free full breakfast, and free parking. TownePlace Suites by Marriott Sikeston is one more option that features an onsite pool. View all hotels with pools in Sikeston.
What's the best place to stay near Barkley Regional Airport (PAH)?
Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.
What is staying in Sikeston like?
Families will find kid-friendly activities in Sikeston, and visitors give high marks for the top-notch restaurants and shopping. This welcoming city also attracts tourists with its riverfront and university setting. In Sikeston, there are 15 hotels and other accommodations to choose from. Find out more about Sikeston.
What are the top places to visit in Sikeston?
A couple of favorite places to visit are Sikeston Depot Museum and Central Park. You'll also find Front Street Studio & Art Gallery and Stoddard County Civil War Memorial Cemetery in the area. Check out what more to see and do in Expedia's Sikeston guide.
What's the seasonal weather like in Sikeston?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.

Explore a world of travel with Expedia