The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

Our top choices for Florida Keys National Marine Sanctuary hotels

Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds

Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Jimmy

AED 988 total

includes taxes & fees

9 Jun - 10 Jun

Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Jennifer

AED 852 total

includes taxes & fees

11 Jun - 12 Jun

Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Michael

AED 988 total

includes taxes & fees

9 Jun - 10 Jun

Queen with Pool View | Minibar, in-room safe, individually decorated, individually furnished

Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

Olha

AED 613 total

includes taxes & fees

7 Jun - 8 Jun

Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Matthew

AED 495 total

includes taxes & fees

9 Jun - 10 Jun

The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Julian

AED 1,483 total

includes taxes & fees

8 Jun - 9 Jun

The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Lucy

AED 883 total

includes taxes & fees

9 Jun - 10 Jun

11 Gecko's Garden - Adults Only | Premium bedding, pillowtop beds, individually decorated

Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Akhenaton

AED 790 total

includes taxes & fees

8 Jun - 9 Jun

Premium bedding, iron/ironing board, free WiFi, bed sheets

Weatherstation Inn

Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary

A. Elise

AED 666 total

includes taxes & fees

7 Jun - 8 Jun

Deluxe Suite, 1 King Bed, Private Pool | View from room

H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Elizabeth

AED 1,607 total

includes taxes & fees

8 Jun - 9 Jun

Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Brinkley

AED 837 total

includes taxes & fees

8 Jun - 9 Jun

L'Habitation Guest House

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Megan

AED 574 total

includes taxes & fees

8 Jun - 9 Jun

Cigar House King Suite w/ Poolside porch | Balcony view

Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Troy

AED 716 total

includes taxes & fees

8 Jun - 9 Jun

Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

gerald

AED 736 total

includes taxes & fees

17 Jun - 18 Jun

Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Robert

AED 1,012 total

includes taxes & fees

23 Jun - 24 Jun

Superior Studio Suite, 1 King Bed with Sofa bed, Accessible, Refrigerator & Microwave | Free WiFi, bed sheets

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Annette

AED 887 total

includes taxes & fees

8 Jun - 9 Jun

Outdoor pool, open 8:00 AM to 10:00 PM, sun loungers

Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Nanci

AED 818 total

includes taxes & fees

29 Jun - 30 Jun

The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Jacqueline

AED 635 total

includes taxes & fees

9 Jun - 10 Jun

3 outdoor pools, a heated pool, sun loungers

Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Lori

AED 809 total

includes taxes & fees

7 Jun - 8 Jun

Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Jill

AED 1,525 total

includes taxes & fees

21 Jun - 22 Jun

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	3.5 star property	10.0 Exceptional 1,005 reviews	View
Key West Villas	3.5 star property	9.8 Exceptional 262 reviews	View
Orchid Key Inn - Adults Only	3.5 star property	9.8 Exceptional 1,005 reviews	View
Simonton Court Historic Inn & Cottages	2.5 star property	9.8 Exceptional 972 reviews	View
Douglas House - Adults Only	3.0 star property	9.6 Exceptional 410 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Wicker Guesthouse

4/10 Poor

"When we arrived it was after dark. Lady at the desk gave us a map and sent us on our way. We walked around streets for about 10/15mins trying to find our room in the dark. Finally called the lady at the desk and she came and showed us. Should have done that in the first place seeing where the room was. It was down a dark walkway, then through a dark breezeway, down a small, narrow dark walkway that led us to our “hidden” room. When it rained, the rain spout poured right into the walkway of our room leaving several inches of standing water. Room was extremely small. Was advertised as a queen bed, it was a full size at most. Pool was nice. The outside of the building definitely needs a major facelift."

Southernmost Beach Resort and Guesthouses

2/10 Terrible

"This facility is spread over approximately 6 acres. Nothing is done in the same building. We are 80 years old. When we arrived at the hotel we were told that our room was five blocks away when I told them that that was impossible for my husband to walk, they offered us in a room for an additional $50 a night plus $65 fee to use the amenities bringing the charge to our room approximately $550 when we saw our room, we realized that it was on the second floor with stairs and no elevator. The room was so small that in order to open the closet you needed to sit on the bed. There was no chair in the room no coffee and tea service even though it was listed and no telephone even though local calls were supposed to be provided free of charge. Breakfast was included in our room and we found out the first morning that breakfast again was in another building outside around the corner across the street the beach consisted of beach chairs, sand, and seaweed from end to end so there was no option to go in the water. I would not recommend this hotel to anyone Holiday Inn best Western, etc. at $200 per night or 10 times better."

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

4.4/5 (128 reviews)

You can spend an afternoon studying the exhibits at Florida Keys Eco - Discovery Center during your travels in Key West. Discover the area's lively bars and its lively festivals.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1537 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Caribbean House is one of the top choices for your stay based on our traveler data, and this B&B offers free breakfast and private balconies. Other good choices close by include La Concha Key West, Autograph Collection and Southernmost Beach Resort and Guesthouses.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1537 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Key West Burlesque Theater, and Key West Film Society if you're interested in local theater.

Find hotels near Florida Keys National Marine Sanctuary, Key West from AED 495

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Our top choices for Florida Keys National Marine Sanctuary hotels

Almond Tree Inn Hotel - Adults Only

Key West Villas

Orchid Key Inn - Adults Only

Simonton Court Historic Inn & Cottages

Douglas House - Adults Only

The Marquesa Hotel

The Conch House Heritage Inn

Tropical Inn

Weatherstation Inn

H2O Suites - Adults Only

Coco Plum Inn

L'Habitation Guest House

Island City House Hotel

Duval House

Marrero's Guest Mansion

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Ella's Cottages - Key West Historic Inns

The Grand Guesthouse

Ambrosia Key West

Santa Maria Suites

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Wicker Guesthouse

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

Frequently asked questions

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Hotels near popular Key West Attractions

Other Hotels near Florida Keys National Marine Sanctuary, Key West

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