Photo by Cindy Keese

Find Resorts & Hotels with Spas in Seneca, SC

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Check availability on Seneca Resorts & Hotels with Spas

Tonight
29 May - 30 May
Tomorrow
30 May - 31 May
This weekend
30 May - 1 Jun
Next weekend
6 Jun - 8 Jun

Compare Seneca Resorts & Hotels with Spas room rates, reviews, and availability. Most hotels are fully refundable.

Lakeside Lodge Clemson
Aerial view

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (885)
"Absolutely beautiful property & the room was the best I've ever stayed! "
The price is AED 400
AED 494 total
includes taxes & fees
5 Jun - 6 Jun
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Terrace/patio

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (718)
"Had such a nice stay- comfy rooms and convenient location to shopping & dining!"
The price is AED 403
AED 443 total
includes taxes & fees
11 Jun - 12 Jun
Tru by Hilton Seneca Clemson
Quality Inn Seneca US-123
Room, 2 Double Beds, Accessible, Non Smoking | Pillowtop beds, desk, laptop workspace, blackout drapes

Quality Inn Seneca US-123

2.5 star property
8.0 out of 10, Very Good, (590)
"Nice place for the price. I would stay here again. Looks newly renovated and was clean. Very comfy bed, pillows. Breakfast was basic but delicious. Staff was excellent. Very pleasant and professional. We enjoyed our short stay. "
The price is AED 294
AED 360 total
includes taxes & fees
5 Jun - 6 Jun
Quality Inn Seneca US-123
Days Inn by Wyndham Seneca / Clemson Area
Lobby

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (680)
"Clean and comfortable. Good location. Close to Clemson University "
The price is AED 253
AED 278 total
includes taxes & fees
15 Jun - 16 Jun
Days Inn by Wyndham Seneca / Clemson Area
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
Outdoor spa tub

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

10.0 out of 10, Exceptional, (141)
"Great set up for family Christmas reunion "
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
Best Western Seneca-Clemson
Lobby

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very Good, (591)
"Rooms were very clean and nice. Good breakfast options. Friendly staff, very accommodating."
The price is AED 340
AED 374 total
includes taxes & fees
10 Jun - 11 Jun
Best Western Seneca-Clemson
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Fridge, microwave, oven, stovetop

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10.0 out of 10, Exceptional, (84)
"Great stay!"
The price is AED 3,783
AED 6,969 total
includes taxes & fees
5 Jun - 6 Jun
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
The HART of Tiger Town! Lakefront home less than 4 miles to Clemson University
Miscellaneous

The HART of Tiger Town! Lakefront home less than 4 miles to Clemson University

7.0 out of 10, Good, (2)
"Thank you so much for letting us use your house. One of the guests who has ALS slipped out the shower and broke off the front corner of the lip to the toilet bowl. I have left money in the kitchen drawer to the right of the dishwasher to cover the expense"
The HART of Tiger Town! Lakefront home less than 4 miles to Clemson University
Serenity Bay on Lake Keowee!
Exterior

Serenity Bay on Lake Keowee!

2.0 star property
Serenity Bay on Lake Keowee!
Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!
Exterior

Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!

10.0 out of 10, Exceptional, (106)
"We had two familes stay and had a great time at the lake. The house was clean and in a calm cove on the lake, convient to town and the restaurants on the lake."
Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
How many spa hotels will I find in Seneca?
Among Expedia’s 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Keowee Reservoir, Lake Keowee, and Keowee Key Golf Course. If you have extra time while you’re in the area, you might want to see Lake Hartwell and Cross Creek Plantation Golf.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.