Photo by Cindy Keese

Find Resorts & Hotels with Spas in Seneca, SC

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Check availability on Seneca Resorts & Hotels with Spas

Top Seneca Resorts & Hotels with Spas

Lakeside Lodge Clemson
Aerial view

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (943)
"Great overall stay."
The price is AED 364
AED 451 total
includes taxes & fees
16 Jul - 17 Jul
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Lobby

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (736)
"Great overall stay."
The price is AED 450
AED 495 total
includes taxes & fees
23 Jul - 24 Jul
Tru by Hilton Seneca Clemson
Quality Inn Seneca Clemson Area US-123
Free daily on-the-go breakfast

Quality Inn Seneca Clemson Area US-123

2.5 star property
8.0 out of 10, Very Good, (609)
"I am very clean staff very, very friendly good location"
The price is AED 294
AED 360 total
includes taxes & fees
21 Jul - 22 Jul
Quality Inn Seneca Clemson Area US-123
Days Inn by Wyndham Seneca / Clemson Area
Lobby

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (690)
"The property was near the area that I needed to be in. It has ample shops and restaurants in the area "
The price is AED 250
AED 275 total
includes taxes & fees
20 Jul - 21 Jul
Days Inn by Wyndham Seneca / Clemson Area
Best Western Seneca-Clemson
Lobby

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very Good, (594)
"The admission attendant was friendly"
The price is AED 340
AED 374 total
includes taxes & fees
22 Jul - 23 Jul
Best Western Seneca-Clemson
Carolina’s Cottage Cove-Lake Keowee
Outdoor spa tub

Carolina’s Cottage Cove-Lake Keowee

9.6 out of 10, Exceptional, (19)
"We absolutely LOVED this house and would love to stay again! Next time a little longer! "
Carolina’s Cottage Cove-Lake Keowee
The HART of Tiger Town! Lakefront home less than 4 miles to Clemson University
Fridge, microwave, oven, stovetop

The HART of Tiger Town! Lakefront home less than 4 miles to Clemson University

7.0 out of 10, Good, (2)
"Thank you so much for letting us use your house. One of the guests who has ALS slipped out the shower and broke off the front corner of the lip to the toilet bowl. I have left money in the kitchen drawer to the right of the dishwasher to cover the expense"
The HART of Tiger Town! Lakefront home less than 4 miles to Clemson University
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
Outdoor spa tub

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

10.0 out of 10, Exceptional, (144)
"Great set up for family Christmas reunion "
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Fridge, microwave, oven, stovetop

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10.0 out of 10, Exceptional, (84)
"We had a perfect family vacation on the lake. The layout and design of the property is so thoughtful and well done. There was plenty of space for our large group to spread out, play, and relax. The kitchen is well appointed with everything you need entertain. We could not have had a better time. "
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger
Fridge, microwave, oven, stovetop

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

9.8 out of 10, Exceptional, (121)
"We were so pleased with this home and our overall stay at this property. The kitchen was very well stocked, it was very spacious, kayaks were such a fun bonus! "
The price is AED 1,653
AED 2,949 total
includes taxes & fees
17 Jul - 18 Jul
Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
How many spa hotels will I find in Seneca?
Among Expedia's 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Lake Keowee, Keowee Key Golf Course, and Lake Hartwell. If you have extra time while you're in the area, you might want to see Oconee County Library Seneca Branch and Keowee Reservoir.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.