10 Best Motels in Southeast Missouri: Find Cheap Motels in Southeast Missouri, MO 2026

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Our top choices for Southeast Missouri motels

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

1. Super 8 by Wyndham Farmington

Farmington

Marisa

AED 250 total

includes taxes & fees

15 Nov - 16 Nov

A motel with a covered entrance, a flag, and a phone number.

2. Madison Inn Lodge

Fredericktown

Bawan

AED 341 total

includes taxes & fees

10 Nov - 11 Nov

A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

3. Motel 6 Poplar Bluff, MO

Poplar Bluff

Jim

AED 292 total

includes taxes & fees

22 Nov - 23 Nov

A room with a wooden floor, a bed, a desk with a coffee maker, a mirror, and a sliding door leading to a bathroom.

4. Black River Motel and Restaurant

Lesterville

Douglas

AED 501 total

includes taxes & fees

10 Nov - 11 Nov

A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.

5. Econo Lodge Dexter

Dexter

Herman

AED 212 total

includes taxes & fees

8 Dec - 9 Dec

A bedroom with a bed, a desk, and a chair. There is a window with curtains, a radiator, and a wall-mounted shelf with a towel.

6. Current River Inn

Van Buren

Sarah

AED 433 total

includes taxes & fees

10 Nov - 11 Nov

A hotel room with a brick exterior, a sliding glass door, a window with a view, and a built-in heater.

7. Rosener's Inn and banquet center

Park Hills

Jose

AED 363 total

includes taxes & fees

13 Nov - 14 Nov

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

8. Country Yard Inn and Suite

Sikeston

Marianne

AED 240 total

includes taxes & fees

10 Nov - 11 Nov

A hotel room with two beds, a TV, a mirror, a wardrobe, and a desk.

9. OYO Hickory House Inn

Dexter

DIEGO

AED 230 total

includes taxes & fees

23 Nov - 24 Nov

A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.

10. Town House Inn Cape Giradreau

Cape Girardeau

Jaime

AED 322 total

includes taxes & fees

10 Nov - 11 Nov

A living room with a sofa, coffee table, and a small table with a vase. There is a window with blinds and a door in the background.

11. Super 8 by Wyndham Bonne Terre

Bonne Terre

Elizabeth

AED 246 total

includes taxes & fees

10 Nov - 11 Nov

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

12. Eagle Inn Charleston

Charleston

Jackson

AED 271 total

includes taxes & fees

10 Nov - 11 Nov

A modern hotel room with a large bed, a desk with a lamp, a TV, and a wardrobe.

13. Motel 6 Bonne Terre, MO

Bonne Terre

Kathleen

AED 266 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

14. Super 8 by Wyndham Perryville

Perryville

Matthew

AED 289 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

15. Super 8 by Wyndham Potosi

Potosi

Clay

AED 234 total

includes taxes & fees

13 Nov - 14 Nov

16. Super 8 by Wyndham Pevely

Pevely

Steve

AED 247 total

includes taxes & fees

8 Dec - 9 Dec

A hotel room with two beds, a desk with a computer, a TV, and a bathroom with a bathtub.

17. Super 8 by Wyndham Poplar Bluff Missouri

Poplar Bluff

Michael

AED 265 total

includes taxes & fees

15 Nov - 16 Nov

A staircase with wooden steps and metal handrails, leading to an upper floor.

18. Rockwood Inn Kennett I 55 Near Blytheville

Kennett

James

AED 275 total

includes taxes & fees

10 Nov - 11 Nov

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

19. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

zandra

AED 241 total

includes taxes & fees

1 Dec - 2 Dec

A hotel bathroom with a bathtub, a shower, and a toilet. There is a towel rack and a sign on the wall.

20. Super 8 by Wyndham Cuba

Cuba

Damon

AED 309 total

includes taxes & fees

15 Nov - 16 Nov

View all properties

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top reviews in Southeast Missouri

Super 8 by Wyndham Perryville

Perryville

10/10 Excellent

DAN

Current River Inn

Van Buren

10/10 Excellent

Isaac

Super 8 by Wyndham Farmington

Farmington

10/10 Excellent

MarBella

Madison Inn Lodge

Fredericktown

10/10 Excellent

Anonymous traveler

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.

Town House Inn

Jackson

10/10 Excellent

larry

Super 8 by Wyndham Potosi

Potosi

10/10 Excellent

Anonymous traveler

Super 8 by Wyndham Cuba

Cuba

10/10 Excellent

Tim

A building entrance with a stone pillar, a black door, and decorative dried corn stalks.

Mammoth Spring Lodge Motel

Thayer

10/10 Excellent

This town has a world class natural spring that creates a small lake but feeds a river with fun canoeing and awesome rainbow trout fishing, but the closest major chain is about a 20-30 minutes away. The Mammoth Spring Lodge sits across from the spring with a beautiful view. The room was spotless and comfortable. The complimentary breakfast was average, but there was a good variety. The staff was friendly. We will definitely stay here again.

Sam

A hotel room with two beds, a desk, a chair, a lamp, and a painting on the wall.

Americas Best Value Inn Sullivan

Sullivan

10/10 Excellent

Donna

A room with two beds, wooden walls, a wooden floor, a mirror, a lamp, and a small table.

Country Inn Motel

Licking

10/10 Excellent

Jason

A hotel room with two beds, a desk, a mirror, and a view of the city.

Motel 6 Dyersburg, TN

Dyersburg

10/10 Excellent

I didn't spend a lot of time in the room because of visiting with family but the room was nice and comfortable. The shower was AMAZING! Large and I want one just like it at home! The dresser and desk were a little large for the size of the room but very nice overall. My main problem with the Executive Inn and Suites is the lobby is so small that most of my family stays at the Hampton so they can visit in the evenings and at breakfast in the morning.

Rose M

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Search Motels in Southeast Missouri

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Southeast Missouri motels

1. Super 8 by Wyndham Farmington

2. Madison Inn Lodge

3. Motel 6 Poplar Bluff, MO

4. Black River Motel and Restaurant

5. Econo Lodge Dexter

6. Current River Inn

7. Rosener's Inn and banquet center

8. Country Yard Inn and Suite

9. OYO Hickory House Inn

10. Town House Inn Cape Giradreau

11. Super 8 by Wyndham Bonne Terre

12. Eagle Inn Charleston

13. Motel 6 Bonne Terre, MO

14. Super 8 by Wyndham Perryville

15. Super 8 by Wyndham Potosi

16. Super 8 by Wyndham Pevely

17. Super 8 by Wyndham Poplar Bluff Missouri

18. Rockwood Inn Kennett I 55 Near Blytheville

19. Super 8 by Wyndham Charleston/Sikeston East MO

20. Super 8 by Wyndham Cuba

Learn more about Southeast Missouri

Top reviews in Southeast Missouri

Super 8 by Wyndham Perryville

10/10 Excellent

Explore a world of travel with Expedia