The Best Business Hotels in St. Louis, MO from AED 301 in 2026 | Expedia

A large white building with a dome and a statue in front, surrounded by fountains and trees.

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Check availability on St. Louis Business Hotels

Tonight

23 Oct - 24 Oct

Tomorrow

24 Oct - 25 Oct

This weekend

23 Oct - 25 Oct

Next weekend

Our top choices for St. Louis business-friendly hotels

A rooftop terrace with wicker furniture, offering a city view.

A hotel room with a large window offering a view of the Gateway Arch and a modern building.

A lobby with seating areas, a chandelier, and a large pillar.

A modern hotel lobby with a bar area, seating arrangements, and a large chandelier.

1. Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis

United States

Theresa

AED 496

AED 580 total

includes taxes & fees

28 Oct - 29 Oct

A lobby with a sofa, two armchairs, a coffee table, and a staircase.

A park with a pathway, trees, and a modern sculpture.

A spacious lobby with a sectional sofa, a white armchair, and a glass coffee table. There is a dining area in the background with a chandelier.

A rooftop lounge with large windows, red seating, and a view of the cityscape.

2. Hyatt Regency St. Louis at The Arch

Downtown St. Louis

United States

Johnny

AED 493

AED 581 total

includes taxes & fees

30 Oct - 31 Oct

A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

A seating area with three grey armchairs and a central glass-top table, a wooden floor, and a view of parked cars through large windows.

A spacious indoor area with a high ceiling and large windows, featuring multiple seating areas with sofas and chairs, and a visible outdoor view through the windows.

A spacious indoor area with multiple wooden tables and chairs, large windows, and a high ceiling with exposed beams.

3. Pear Tree Inn St. Louis Airport

St. Ann

United States

Curtiss

AED 331

AED 392 total

includes taxes & fees

29 Oct - 30 Oct

An indoor pool area with a hot tub, seating, and a stone wall.

Exterior

A buffet setup with a marble counter, glass railings, and a variety of food containers.

A hotel room with a sofa, a small table with a lamp, a bed, and two framed pictures on the wall.

4. Drury Plaza Hotel St. Louis Union Station

Downtown West

United States

Andrea

AED 415

AED 494 total

includes taxes & fees

1 Nov - 2 Nov

A modern living room with a built-in fireplace, a large flat-screen TV, a unique hexagonal pendant light, and a patterned rug.

A modern dining area with a long table, multiple chairs, and a unique chandelier.

A modern lobby with blue seating, a reception desk, and large windows.

A corridor with snack bags, a refrigerator stocked with Mountain Dew, and a view into a room with a ceiling fan.

5. Hyatt Select St. Louis Airport

Woodson Terrace

United States

Daisy

AED 404

AED 501 total

includes taxes & fees

29 Oct - 30 Oct

A modern hotel room with a dining area, wooden cabinets, a checkered floor, and a flat-screen TV.

A hotel room with a desk, chair, TV, and a framed picture on the wall.

A lobby with two orange armchairs, a small table, a flat-screen TV, framed pictures, and a wall-mounted shelf with decorative items.

A hotel room with two beds, a desk, a chair, and a large window with curtains.

6. Wingate by Wyndham St. Louis Airport

St. Ann

United States

Cindy

AED 330

AED 391 total

includes taxes & fees

29 Oct - 30 Oct

A multi-story hotel with a prominent corner location, large windows, and a well-lit facade.

A buffet area with various food items and a self-service station.

A bar area with a long counter, multiple stools, and a television mounted on the wall.

A spacious lobby with striped chairs, a central coffee table, and large potted plants.

7. Embassy Suites by Hilton St. Louis Downtown

Downtown St. Louis

United Kingdom

Luke

AED 418

AED 498 total

includes taxes & fees

23 Nov - 24 Nov

A swimming pool with a metal ladder, surrounded by chairs and large windows offering a view of the sunset.

A modern hotel lobby with a seating area, a desk, and large windows offering a view of the outside.

A modern dining area with multiple tables and chairs, large windows offering a view of the outdoors, and a mix of natural and artificial lighting.

A modern hotel with a prominent 'La Quinta' sign, large windows, and a covered entrance area.

8. La Quinta Inn & Suites by Wyndham St Louis Route 66

St. Louis

United States

Edward

AED 365

AED 425 total

includes taxes & fees

25 Oct - 26 Oct

View all properties

Top St. Louis Hotel Reviews

Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

10/10 Excellent

"Everything was good. Great location"

Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent

"Loved the location, amenities and large room with comfortable bed. We were able to walk to Enterprise Center. Particularly enjoyed the happy hour and breakfast. Did not appreciate the noise from the garbage collectors handling the huge dumpsters around 4am. For an upscale quality hotel you should contract to have quiet hours like midnight to 8am with any businesses your guest rooms face."

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

10/10 Excellent

"Great place"

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

10/10 Excellent

"Family friendly helpful polite Cheerful. I truefully don’t have all the words to how amazing this stay was."

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent

"Everything was Great - Will stay there again"

Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent

"We enjoyed the fresh popcorn and it was within walking distance from the train station."

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