The Best Business Hotels in St. Louis, MO from AED 287 in 2026 | Expedia

A large white building with a dome and a statue in front, surrounded by fountains and trees.

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Check availability on St. Louis Business Hotels

Tonight

18 Oct - 19 Oct

Tomorrow

19 Oct - 20 Oct

Next weekend

23 Oct - 25 Oct

In two weeks

Our top choices for St. Louis business-friendly hotels

A rooftop terrace with wicker furniture, offering a city view.

A hotel room with a large window offering a view of the Gateway Arch and a modern building.

A spacious lobby with a blue sofa, a glass coffee table, and a chandelier.

A modern hotel lobby with a bar area, seating arrangements, and a large chandelier.

1. Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis

United States

Theresa

AED 496

AED 580 total

includes taxes & fees

25 Oct - 26 Oct

A lobby with a sofa, two armchairs, a coffee table, and a staircase.

A park with a pathway, trees, and a modern sculpture.

A modern hotel room with a large window, a flat-screen TV mounted on the wall, a round dining table with chairs, and a patterned rug.

A spacious lobby with a sectional sofa, a white armchair, and a glass coffee table. There is a dining area in the background with a chandelier.

2. Hyatt Regency St. Louis at The Arch

Downtown St. Louis

United States

David

AED 493

AED 581 total

includes taxes & fees

30 Oct - 31 Oct

A multi-level hotel lobby with seating areas, a reception desk, and large windows offering views.

A hotel room with a bed, two armchairs, a sofa, a small table, and a nightstand.

A hotel reception area with a counter, seating, and a staircase.

A pool area with two hot tubs, seating, and a view of the outdoors.

3. Drury Inn & Suites St. Louis Airport

Edmundson

United States

Ethan

AED 422

AED 500 total

includes taxes & fees

25 Oct - 26 Oct

An indoor swimming pool with a hot tub, lounge chairs, and a brick wall with artwork.

Property amenity

A multi-story hotel with a prominent sign for 'Pearl Tree Inn by O'Dell'.

4. Pear Tree Inn St. Louis Near Union Station

Downtown West

United States

Samantha

AED 382

AED 447 total

includes taxes & fees

25 Oct - 26 Oct

A modern hotel room with a dining area, wooden cabinets, a checkered floor, and a flat-screen TV.

A hotel room with two beds, a desk, a chair, and a large window with curtains.

A lobby with two orange armchairs, a small table, a flat-screen TV, framed pictures, and a wall-mounted shelf with decorative items.

A hotel room with a desk, chair, TV, and a framed picture on the wall.

5. Wingate by Wyndham St. Louis Airport

St. Ann

United States

Mary

AED 356

AED 422 total

includes taxes & fees

25 Oct - 26 Oct

A modern outdoor lounge area with seating, a bar, and a view of a cityscape.

The exterior of the Clark & Bourbon hotel with a well-lit entrance, a marquee sign, and a landscaped planter area.

A modern bar area with a central fire feature, bar stools, and seating.

A restaurant with tables set for dining, a kitchen in the background, and hanging light fixtures.

6. Live by Loews - St.Louis

Downtown St. Louis

United States

Molly

AED 511

AED 607 total

includes taxes & fees

15 Nov - 16 Nov

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

A swimming pool with a tiled deck, a sunlit room with a view, and a seating area with chairs.

A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.

A hotel room with three computer workstations, each with a monitor, keyboard, and a lamp.

7. Hyatt Place St. Louis/Chesterfield

Chesterfield

United States

Debbie

AED 443

AED 514 total

includes taxes & fees

25 Oct - 26 Oct

The Clayton Plaza Hotel sign with a stone wall and plants in front.

A living room with a brown leather sofa, a small table, and a chair. There is a window with curtains, a lamp, and a framed picture on the wall.

A hotel room with two beds, a desk, a chair, and a television.

A lobby with a chandelier, a round table with a floral arrangement, and a painting on the wall.

8. Clayton Plaza Hotel & Extended Stay

Clayton

United States

Sarah

AED 340

AED 397 total

includes taxes & fees

1 Nov - 2 Nov

View all properties

Top St. Louis Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent

"Great location and amazing staff. Also afternoon snacks and drinks are great additions."

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

10/10 Excellent

"The staff were friendly and very helpful!💜"

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent

"I liked the room design with modern features and it was clean. The coffee maker and coffee helped me start my day. The shuttle service took me to the airport early morning. Friendly driver & dropped me right where I needed to go."

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

10/10 Excellent

"Enjoyed my stay with family at the property. The staff were friendly, helpful and accommodating."

Moonrise Hotel

Moonrise Hotel

10/10 Excellent

"Had the Vincent Price suite with a city view. Also loved the rooftop terrace."

Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

10/10 Excellent

"Easy check in"

Forest Park Hotel by MDR

Forest Park Hotel by MDR

10/10 Excellent

"Great, great, great property. well restored, you know, rung back. You tell us it’s buildings older. Amenities are great. Staff’s great, clean. go above and beyond to try to be helpful as much as they can. I felt safe. Yeah, all around good property"

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