The Best Business Hotels in St. Louis, MO from AED 301 in 2026 | Expedia

A large white building with a dome and a statue in front, surrounded by fountains and trees.

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Check availability on St. Louis Business Hotels

Tonight

21 Oct - 22 Oct

Tomorrow

22 Oct - 23 Oct

This weekend

23 Oct - 25 Oct

Next weekend

Our top choices for St. Louis business-friendly hotels

A rooftop terrace with rows of metal chairs and a view of city buildings.

A lobby with seating areas, a chandelier, and a large pillar.

A hotel room with a large window offering a view of the Gateway Arch and a modern building.

A spacious lobby with a blue sofa, a glass coffee table, and a chandelier.

1. Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis

United States

Theresa

AED 496

AED 580 total

includes taxes & fees

26 Oct - 27 Oct

A lobby with a sofa, two armchairs, a coffee table, and a staircase.

A rooftop lounge with large windows, red seating, and a view of the cityscape.

A park with a pathway, trees, and a modern sculpture.

A spacious lobby with a sectional sofa, a white armchair, and a glass coffee table. There is a dining area in the background with a chandelier.

2. Hyatt Regency St. Louis at The Arch

Downtown St. Louis

United States

Johnny

AED 493

AED 581 total

includes taxes & fees

30 Oct - 31 Oct

A multi-level hotel lobby with seating areas, a reception desk, and large windows offering views.

A hotel reception area with a counter, seating, and a staircase.

A modern kitchen with a stainless steel range hood, a bar area with stools, and a large window providing a view of the outdoors.

A hotel room with a bed, two armchairs, a sofa, a small table, and a nightstand.

3. Drury Inn & Suites St. Louis Airport

Edmundson

United States

Ethan

AED 422

AED 500 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

A spacious indoor area with a high ceiling and large windows, featuring multiple seating areas with sofas and chairs, and a visible outdoor view through the windows.

A hotel room with a bed, a desk, a television, and a lamp.

A spacious indoor area with multiple wooden tables and chairs, large windows, and a high ceiling with exposed beams.

4. Pear Tree Inn St. Louis Airport

St. Ann

United States

Curtiss

AED 331

AED 392 total

includes taxes & fees

26 Oct - 27 Oct

A multi-story hotel with a prominent corner location, large windows, and a well-lit facade.

A buffet area with various food items and a self-service station.

A spacious lobby with striped chairs, a central coffee table, and large potted plants.

An indoor swimming pool area with lounge chairs, a small table, and potted plants.

5. Embassy Suites by Hilton St. Louis Downtown

Downtown St. Louis

United Kingdom

Luke

AED 434

AED 516 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel room with a dining area, wooden cabinets, a checkered floor, and a flat-screen TV.

A hotel room with two beds, a desk, a chair, and a large window with curtains.

A lobby with two orange armchairs, a small table, a flat-screen TV, framed pictures, and a wall-mounted shelf with decorative items.

A hotel room with a desk, chair, TV, and a framed picture on the wall.

6. Wingate by Wyndham St. Louis Airport

St. Ann

United States

Rachal

AED 372

AED 441 total

includes taxes & fees

1 Nov - 2 Nov

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

A hotel room with three computer workstations, each with a monitor, keyboard, and a lamp.

A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.

A modern hotel entrance with a glass canopy, large windows, and a brick facade.

7. Hyatt Place St. Louis/Chesterfield

Chesterfield

United States

Debbie

AED 443

AED 514 total

includes taxes & fees

25 Oct - 26 Oct

An indoor swimming pool with clear glass ceilings, large windows, and a sunlit area with umbrellas.

A hotel dining area with multiple tables and chairs, a central island, and pendant lighting.

A compact minibar with a refrigerator, coffee maker, and beverage dispensers.

A hotel with a prominent arch structure in the background, a sign for Hampton Inn, and a TGI Friday's restaurant.

8. Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Downtown St. Louis

United States

Andrew

AED 404

AED 472 total

includes taxes & fees

28 Oct - 29 Oct

View all properties

Top St. Louis Hotel Reviews

Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent

"Staff was great and very helpful. Breakfast was good and Hot. Evening snacks and drinks was a plus. Room and hallway was clean and maintained. Elevator was clean and quick, parking was plentiful and a plus that it was included. Close to union station for walking, felt safe."

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

8/10 Good

"Our stay was great but the beds are absolutely horrible. Please get me mattresses"

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

10/10 Excellent

"Room was quite large and very comfortable."

Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

10/10 Excellent

"Clean room nice wonderful staff"

Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent

"The staff were friendly and helpful. It was a wonderful stay a around"

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