The Best Hotels Closest to St. Louis Science Center in St. Louis for 2026

A space shuttle exhibit with a large model of a space shuttle, a red pillar, and informational displays.

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Our top choices for St. Louis Science Center hotels

Two coffee roasters, 'Bold' and 'Decaf', by Kelso+Bros, with a forest-themed design.

A Drury Inn & Suites hotel with a parking lot and several cars.

1. Drury Inn & Suites St. Louis Forest Park

2 km from St. Louis Science Center

Tammy

AED 496

AED 580 total

includes taxes & fees

1 Nov - 2 Nov

A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.

A restaurant with multiple dining tables and chairs, a bar area with shelves of bottles, and a large mirror above the bar.

A grand lobby with a central seating area, a staircase, and a decorative ceiling.

A bar area with a marble counter, bar stools, and a variety of liquor bottles.

2. The Royal Sonesta Chase Park Plaza St. Louis

Central West End, 1.8 km from St. Louis Science Center

Kristina

AED 492

AED 689 total

includes taxes & fees

22 Nov - 23 Nov

A modern living room with a fireplace, sofas, a coffee table, and a bookshelf.

A hotel with a modern facade, large windows, and a sign reading "AC HOTEL CENTRAL WEST END".

A modern living room with a fireplace, comfortable seating, and a large TV.

A modern kitchen with a marble backsplash, built-in bar with stools, and shelves stocked with bottles.

3. AC Hotel St. Louis Central West End

Central West End, 1.8 km from St. Louis Science Center

Janice

AED 528

AED 622 total

includes taxes & fees

20 Nov - 21 Nov

An outdoor patio area with tables and chairs, string lights, and umbrellas.

A modern bar area with a long counter, bar stools, and a television mounted on the wall.

A modern cafe interior with a bar area, seating, and a menu board.

A group of people sitting on a couch in a well-lit room with a large plant and a floor lamp.

4. Hotel Indigo St Louis - Central West End by IHG

Central West End, 1.7 km from St. Louis Science Center

Lydia

AED 426

AED 543 total

includes taxes & fees

22 Nov - 23 Nov

An outdoor patio area with seating, planters, and a grill.

A modern bar area with a long counter, bar stools, and a variety of bottles.

A spacious lobby with a modern design, featuring a seating area with sofas and armchairs, a reception desk, and a large window providing a view of the interior.

A building with a sign that reads "element by Westin" on a brick wall.

5. Element by Marriott St. Louis Midtown

Midtown, 2.7 km from St. Louis Science Center

Julie

AED 485

AED 567 total

includes taxes & fees

28 Oct - 29 Oct

A hot tub with a wooden deck, surrounded by a bamboo fence, and string lights.

A building with a brick facade, a covered entrance, and a tree adorned with string lights.

A spacious dining area with marble tables and chairs, a kitchen in the background, and a modern ceiling design.

A reception area with a Christmas tree, a neon sign, and a Santa Claus figure.

6. The West End

Central West End, 2.3 km from St. Louis Science Center

Trevor

AED 356

AED 490 total

includes taxes & fees

25 Oct - 26 Oct

A modern building with a prominent blue sign, outdoor seating with a round table and chairs, and a view of the cityscape in the background.

A gym with exercise equipment, a mirrored wall, and a patterned carpet.

A modern hotel with a prominent 'aloft' sign, a 'WXYZ' sign, and a 'Coming Soon' advertisement on the side.

A pool area with clear water, red lounge chairs, and a view of the outside through large windows.

7. Aloft by Marriott St Louis Central West End

Central West End, 1.8 km from St. Louis Science Center

Brittany

AED 418

AED 489 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with a fire pit, cushioned benches, and a covered patio with string lights.

A hotel coffee shop with a coffee machine, mugs, and a buffet area.

A modern indoor seating area with a sofa, tables, and chairs.

A compact kitchen with a stainless steel microwave, a sink, and a coffee maker.

8. Home2 Suites by Hilton St. Louis/Forest Park

The Grove, 0.9 km from St. Louis Science Center

MARY

AED 571

AED 668 total

includes taxes & fees

25 Oct - 26 Oct

A modern hotel room with a large bed, a desk with a chair, a blue armchair, a sofa, a TV, and a large window offering a city view.

A modern kitchen with wooden cabinets, a central island, and a wall display of packaged goods.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a kitchen area with a refrigerator and cabinets.

A spacious lobby with leather sofas, a patterned rug, and a reception desk.

9. DoubleTree by Hilton St. Louis Forest Park

Central West End, 1.3 km from St. Louis Science Center

Loleta

AED 530

AED 625 total

includes taxes & fees

20 Nov - 21 Nov

A spacious foyer with a grand staircase, a piano, and a large rug.

A hallway with wooden doors, a wall-mounted tree decoration, a small table with a plant, and a painting.

A backyard with a stone fire pit, two Adirondack chairs, and a hammock.

A spacious living room with a beige sofa, a dining area with a table and chairs, large windows, and a chandelier.

10. White House at Grand Central

3 km from St. Louis Science Center

Priscilla

AED 279

AED 455 total

includes taxes & fees

26 Oct - 27 Oct

A bedroom with a large bed, a mirror, and a vanity with shelves.

A modern bedroom with a large bed, a sitting area with a sofa and chairs, a vanity with a mirror, and a ceiling fan.

A wall with a large, abstract mirror design.

A room with a grand piano, a round table with a red and white tablecloth, and a statue of a robed figure.

11. Central West End B&B

Central West End, 3 km from St. Louis Science Center

Stacee

AED 574

AED 725 total

includes taxes & fees

29 Oct - 30 Oct

A hotel room with two beds, a chair, a desk, and a large window.

A lobby with seating areas, a reception desk, and a view through glass doors.

A bathroom with a bathtub, toilet, and sink.

A reception desk with a sign reading "Forest Park Hotel" and a clock on the wall.

12. Forest Park Hotel by MDR

The Hill, 1.8 km from St. Louis Science Center

Kevan

AED 248

AED 307 total

includes taxes & fees

23 Nov - 24 Nov

A hotel room with a desk, a television, a bed, a mirror, and a coffee maker.

A Red Roof Plus hotel lobby with two leather chairs, a coffee station, and a sign indicating free Wi-Fi in all rooms.

A Red Roof Plus hotel with a stone facade, a parking lot, and a covered outdoor area.

A reception area with a counter, a clock, and a sign indicating free Wi-Fi availability.

13. Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave

The Hill, 1.8 km from St. Louis Science Center

Sean

AED 276

AED 322 total

includes taxes & fees

26 Oct - 27 Oct

A red brick building with a gabled roof and arched windows.

A bedroom with a wooden bed, blue walls, and a white door.

A hallway with framed artwork on the walls and a poster advertising an event.

A room with blue walls, a ceiling fan, a wooden cabinet, and a checkered chair with a yellow cushion.

14. Benton Park Inn

Benton Park, 5.5 km from St. Louis Science Center

Lindsay

AED 525

AED 614 total

includes taxes & fees

25 Oct - 26 Oct

An indoor swimming pool with clear glass walls, a tiled floor, and a 'Step Down' sign.

A Drury Plaza Hotel with a large parking lot and multiple cars parked in front.

A lobby with a reception desk, seating area with sofas and ottomans, and a patterned rug.

A spa bath with a sign indicating a capacity of 8 persons.

15. Drury Plaza Hotel St. Louis Brentwood

6.5 km from St. Louis Science Center

angelia

AED 470

AED 558 total

includes taxes & fees

1 Nov - 2 Nov

A log cabin with a stone chimney, a porch with a stone railing, and a staircase leading to the entrance.

A rustic wooden interior with a wooden bench displaying various animal carvings and a stone wall.

A cozy bedroom with a stone fireplace, a bed with a patterned bedspread, and a television on a wooden stand.

A stone fireplace with a wooden mantel, surrounded by rustic decor and a wooden ceiling.

16. The Lodge at Grant's Trail

10.1 km from St. Louis Science Center

Sherri

AED 666

AED 773 total

includes taxes & fees

27 Oct - 28 Oct

A modern outdoor lounge area with seating, a bar, and a view of a cityscape.

A modern bar area with a central fire feature, bar stools, and seating.

The exterior of the Clark & Bourbon hotel with a well-lit entrance, a marquee sign, and a landscaped planter area.

A modern living room with a sofa, coffee table, and bookshelves.

17. Live by Loews - St.Louis

Downtown St. Louis, 6.7 km from St. Louis Science Center

brandon

AED 511

AED 607 total

includes taxes & fees

15 Nov - 16 Nov

A multi-story building with a grand entrance, large windows, and a well-lit facade at night.

A wooden table set for a meal under a tent with string lights, surrounded by chairs on a grassy area.

A dining room with two tables, chairs, a chandelier, and a fireplace.

A hotel room with a four-poster bed, a dining table with chairs, a bedside table with lamps, and a floral-patterned rug.

18. Grand Center Inn

3.5 km from St. Louis Science Center

Leon and Janis

AED 592

AED 698 total

includes taxes & fees

27 Oct - 28 Oct

A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

A hotel room with a bed, a desk, a television, and a lamp.

A spacious indoor area with a high ceiling and large windows, featuring multiple seating areas with sofas and chairs, and a visible outdoor view through the windows.

A seating area with three grey armchairs and a central glass-top table, a wooden floor, and a view of parked cars through large windows.

19. Pear Tree Inn St. Louis Airport

15 km from St. Louis Science Center

Curtiss

AED 331

AED 392 total

includes taxes & fees

27 Oct - 28 Oct

The exterior of the Charles F. Knight Center with a stone facade, large arched entrance, and a sign above the doors.

A buffet setup with various food items, a coffee station, and a refrigerator with beverages.

A courtyard with outdoor seating, a central fountain, and a view of a tower.

A hotel room with two beds, a desk, and a chair.

20. The Knight Center at Washington University

4.3 km from St. Louis Science Center

Rosalyn

AED 475

AED 546 total

includes taxes & fees

22 Nov - 23 Nov

View all properties

Compare popular hotels close to St. Louis Science Center

Property	Property class	Guest rating
Drury Inn & Suites St. Louis Forest Park	9.4 Exceptional 1,025 reviews	View
The Royal Sonesta Chase Park Plaza St. Louis	9.2 Wonderful 1,002 reviews	View
AC Hotel St. Louis Central West End	9.0 Wonderful 858 reviews	View
Hotel Indigo St Louis - Central West End by IHG	8.8 Excellent 1,002 reviews	View
Element by Marriott St. Louis Midtown	8.8 Excellent 846 reviews	View

Hotels recommended for families near St. Louis Science Center

DoubleTree by Hilton St. Louis Forest Park

Central West End

AED 530

AED 625 total

includes taxes & fees

20 Nov - 21 Nov

Home2 Suites by Hilton St. Louis/Forest Park

The Grove

AED 571

AED 668 total

includes taxes & fees

25 Oct - 26 Oct

Hotel Indigo St Louis - Central West End by IHG

Central West End

AED 426

AED 543 total

includes taxes & fees

22 Nov - 23 Nov

The Royal Sonesta Chase Park Plaza St. Louis

Central West End

AED 492

AED 689 total

includes taxes & fees

22 Nov - 23 Nov

An indoor swimming pool with lounge chairs and a pool table, surrounded by large windows.

A hotel with a modern design, featuring a large entrance, multiple floors, and a parking lot.

A spacious room with a long table and chairs, a television mounted on the wall, and a 'Welcome to the Show Nest' sign.

A snack and treat display with various products, including chips and beverages, in a store setting.

Hampton Inn & Suites St. Louis at Forest Park

Dogtown

AED 479

AED 565 total

includes taxes & fees

1 Nov - 2 Nov

Drury Inn & Suites St. Louis Forest Park

Clifton Heights

AED 496

AED 580 total

includes taxes & fees

1 Nov - 2 Nov

A grand building with a fountain in front.

A cozy lounge area with leather sofas, a fireplace, and a bar counter.

A restaurant with a central bar area, seating arrangements, and a fireplace.

A traditional building with a stone facade, large windows, and outdoor seating area with wicker furniture.

The Cheshire

Richmond Heights

AED 545

AED 647 total

includes taxes & fees

1 Nov - 2 Nov

AC Hotel St. Louis Central West End

Central West End

AED 528

AED 622 total

includes taxes & fees

20 Nov - 21 Nov

Top St. Louis Science Center Hotel Reviews

Hampton Inn & Suites St. Louis at Forest Park

10/10 Excellent

"great service, very clean"

Home2 Suites by Hilton St. Louis/Forest Park

10/10 Excellent

"Very clean room staff was awesome. Recommend."

beautiful small house

10/10 Excellent

"One of the best houses I have stayed at! Clean, comfortable, and quiet. The blankets on the bed are nice and cozy. Love the shower/tub, just be careful because it is pretty deep, so the step is pretty high to get in/out. Will definitely stay again!"

Cozy townhouse in the heart of "The Grove". Minutes from Forest Park and Zoo.

10/10 Excellent

"A wonderful place to stay if you want easy access to Forest park, the zoo and even a quick drive downtown. An old brick townhome that has been remodeled but still has old-school charm and imperfections. It was nice to have coffee supplies (filters, powdered creamer, sweeteners) - just bring your favorite grounds. Lots of small local restaurants within walking distance and a coffee shop 10 steps from the front door. We went to the zoo, an escape room, did some shopping. The drive to everything from this location was quick. The host was quick to respond when needed. NOTE ON FIRST WEEK OF OCTOBER: We were there Oct. 2-4 while Oktoberfest at Urban Chestnut Brewing was going on right in front of the house. The whole street was blocked off for the party. GREAT location if you want to attend that weekend event. However, don't book the first week of October if you want a quiet retreat. It was a nice surprise for us, and we enjoyed it."

Cielo Casa on “The Hill” - Hot Tub + Spacious 3BR - Near BJC, SLU & Downtown

10/10 Excellent

"We loved our stay! This home had everything we needed, including a private fenced-in yard. The location was perfect—within walking distance of The Hill and just a quick drive to the Arch and Forest Park. The home was comfortable, convenient, and in a great location. We would definitely stay here again!"

4BR Near Forest Park Zoo & Missouri Botanical Garden | Free Parking | STL

10/10 Excellent

"We had a wonderful time. We were here for a wedding at the Wild Carrot and a pre wedding picnic at Tower Grove park so the location is perfect. We walked to the Science Center. Beds were comfortable and plentiful. I loved having plenty of towels available for all of us. The kitchen had all the dishes, etc that we needed. Everything was clean and inviting. If we are ever back in St. Louis, we certainly would choose this house again. Thank you for helping make our stay comfortable!"

Casa Esma on The Hill - Luxury Couples Retreat w/ Private Hot Tub

10/10 Excellent

"Centralized location with plenty of room and a fenced yard for your furry friends. Close to the hill and walking distance to some amazing restaurants. Host was very responsive and had plenty of ideas for our first visit to the area. Quick drive to the arch and downtown as well union Station and other attractions."

Stunning 3 bedroom Home in the Heart of the Grove

10/10 Excellent

"Great location and nice accommodations. We had young kids and enjoyed the Magic House and zoo."

Historic Cozy Forest Park Home @ Perfect Family Getaway near Downtown

10/10 Excellent

"We had a last minute soccer tournament in St. Louis and needed accommodations to avoid using the tournament hotels. Three dads and 6 players from our team were able to stay and had more than enough room for everyone’s comfort. Not only was the property only 20 minutes from the soccer complex it was also 13 minutes to the Gateway Arch, as well as Busch Stadium were a few of our players were able to take in a Cardinals Game. With early games this gave us areas to explore in St. Louis. Would be a great spot if our family traveled for non soccer related reasons."

Other attractions near St. Louis Science Center

A modern building with large glass windows and a garden with red and pink tulips.

Jewel Box

Explore the great outdoors at Jewel Box, a lovely green space in St. Louis. Amble around the area's lush forest or attend a sporting event.

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A stone fountain with water cascading down a tiered structure, surrounded by a pond and a grassy area with a building in the background.

Forest Park

9.2/10 (3,389 reviews)

After visiting Forest Park, make a plan to see the other sights and activities in St. Louis. Discover the area's entertainment choices and shops.

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A gazebo with columns and a dome roof, surrounded by a pond and greenery.

Pagoda Circle

You can spend an afternoon browsing the exhibits at Pagoda Circle during your trip to St. Louis. Experience the area's fascinating museums or attend a sporting event.

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A theater stage with a variety of neon signs advertising different businesses.

The Muny Theater

8.6/10 (7 reviews)

You can enjoy a show at The Muny Theater during your trip to St. Louis. Amble around the area's lush forest or attend a sporting event.

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Highlands Golf & Tennis Center

Catch an event at Highlands Golf & Tennis Center during your trip to St. Louis. Experience the area's entertainment choices or attend a baseball game.

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Atomic Cowboy

Atomic Cowboy is just one of the places to see in St. Louis, so why not enjoy the other things to explore during your travels?

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Atomic by Jamo

Atomic by Jamo is just one of the places to see in St. Louis, so why not enjoy the other things to explore during your travels?

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Frequently asked questions

What's the area like around St. Louis Science Center?

St. Louis Science Center is located in a welcoming area of St. Louis known for its picturesque gardens and sporting events. If you're looking for a convenient place to stay, check out the 74 hotels and other accommodations you'll find within a mile.

Where is the best place to stay near St. Louis Science Center?

Hampton Inn & Suites St. Louis at Forest Park is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located just a short 0.6 mi (1 km) from St. Louis Science Center. Other good options within a short distance include Home2 Suites by Hilton St. Louis/Forest Park and DoubleTree by Hilton St. Louis Forest Park.

How many hotels will I be able to find near St. Louis Science Center?

Expedia has 74 hotels and other accommodations within a mile from St. Louis Science Center.

If I need to cancel the hotel reservation for my stay near St. Louis Science Center, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available near St. Louis Science Center.

Where can I learn more about changing or cancelling my trip in the area near St. Louis Science Center?

To access more information about changing or cancelling your stay near St. Louis Science Center, go to https://www.expedia.com/service/.

What can I see and do near St. Louis Science Center?

Cathedral Basilica of St. Louis, St. Louis Art Museum, and City Museum feature captivating exhibits. St. Louis Union Station, Jewel Box, and Cherokee Street are monuments to see when you're exploring the area around St. Louis Science Center. You can check out the local talent at The Muny Theater, Fox Theater, and St. Louis Symphony Orchestra.

Find hotels near St. Louis Science Center, St. Louis from AED 307

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Star rating

Guest rating

Our top choices for St. Louis Science Center hotels

1. Drury Inn & Suites St. Louis Forest Park

2. The Royal Sonesta Chase Park Plaza St. Louis

3. AC Hotel St. Louis Central West End

4. Hotel Indigo St Louis - Central West End by IHG

5. Element by Marriott St. Louis Midtown

6. The West End

7. Aloft by Marriott St Louis Central West End

8. Home2 Suites by Hilton St. Louis/Forest Park

9. DoubleTree by Hilton St. Louis Forest Park

10. White House at Grand Central

11. Central West End B&B

12. Forest Park Hotel by MDR

13. Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave

14. Benton Park Inn

15. Drury Plaza Hotel St. Louis Brentwood

16. The Lodge at Grant's Trail

17. Live by Loews - St.Louis

18. Grand Center Inn

19. Pear Tree Inn St. Louis Airport

20. The Knight Center at Washington University

Compare popular hotels close to St. Louis Science Center

Hotels recommended for families near St. Louis Science Center

DoubleTree by Hilton St. Louis Forest Park

Home2 Suites by Hilton St. Louis/Forest Park

Hotel Indigo St Louis - Central West End by IHG

The Royal Sonesta Chase Park Plaza St. Louis

Hampton Inn & Suites St. Louis at Forest Park

Drury Inn & Suites St. Louis Forest Park

The Cheshire

AC Hotel St. Louis Central West End

Top St. Louis Science Center Hotel Reviews

Hampton Inn & Suites St. Louis at Forest Park

Home2 Suites by Hilton St. Louis/Forest Park

beautiful small house

Cozy townhouse in the heart of "The Grove". Minutes from Forest Park and Zoo.

Cielo Casa on “The Hill” - Hot Tub + Spacious 3BR - Near BJC, SLU & Downtown

4BR Near Forest Park Zoo & Missouri Botanical Garden | Free Parking | STL

Casa Esma on The Hill - Luxury Couples Retreat w/ Private Hot Tub

Stunning 3 bedroom Home in the Heart of the Grove

Historic Cozy Forest Park Home @ Perfect Family Getaway near Downtown

Other attractions near St. Louis Science Center

Jewel Box

Forest Park

Pagoda Circle

The Muny Theater

Highlands Golf & Tennis Center

Atomic Cowboy

Atomic by Jamo

Frequently asked questions