Find Business Hotels in Otay Mesa, CA

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Check availability on Otay Mesa Business Hotels

Our top choices for Otay Mesa business-friendly hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very Good, (1561)
"Great place to stay. Really clean and helpful staff "
United States
Zulma
The price is AED 437
AED 497 total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1006)
"Beautiful place "
United States
Joe
The price is AED 387
AED 441 total
includes taxes & fees
21 Dec - 22 Dec
Quality Suites San Diego Otay Mesa

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
Mission Valley
7.8 out of 10, Good, (1007)
"Good value Nice place to stay "
United States
John
The price is AED 342
AED 394 total
includes taxes & fees
21 Dec - 22 Dec
Crowne Plaza San Diego - Mission Valley by IHG

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
Harbor Island
8.2 out of 10, Very Good, (3183)
"Great stay! "
United States
Melissa
The price is AED 411
AED 605 total
includes taxes & fees
5 Jan - 6 January 2026
Sheraton San Diego Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1311)
"great stay! Food was great and my kids loved the pool and location"
United States
ANDREA
The price is AED 432
AED 662 total
includes taxes & fees
16 Dec - 17 Dec
San Diego Mission Bay Resort

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
El Cajon
9.2 out of 10, Wonderful, (1633)
"Nice rooms. Great food at all restaurants "
United States
Steve
Sycuan Casino Resort

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1572)
"Loved our stay "
United States
Jeremy
The price is AED 474
AED 739 total
includes taxes & fees
18 Dec - 19 Dec
Hyatt Regency Mission Bay Spa and Marina

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (738)
"Friendly staff and clean rooms. "
Canada
Justine
The price is AED 379
AED 439 total
includes taxes & fees
28 Dec - 29 Dec
The DEXTRO Little Italy, BW Premier Collection

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
University Heights
9.4 out of 10, Exceptional, (1337)
"My wife loved everything about this vintage hotel."
United States
Eddie
The price is AED 841
AED 965 total
includes taxes & fees
29 Dec - 30 Dec
Lafayette Hotel & Club

Hampton Inn & Suites Imperial Beach San Diego

Hampton Inn & Suites Imperial Beach San Diego
2.5 star property
Imperial Beach
9.4 out of 10, Exceptional, (950)
"Great stay"
United States
Crystal
The price is AED 394
AED 449 total
includes taxes & fees
22 Dec - 23 Dec
Hampton Inn & Suites Imperial Beach San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Otay Mesa Hotel Reviews

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