Find Business Hotels in Otay Mesa, CA
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Our top choices for Otay Mesa business-friendly hotels
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.0 out of 10, Very Good, (1561)
"Great place to stay. Really clean and helpful staff "
Zulma
The price is AED 437
AED 497 total
includes taxes & fees
21 Dec - 22 Dec
7.2 out of 10, Good, (1006)
"Beautiful place "
Joe
The price is AED 387
AED 441 total
includes taxes & fees
21 Dec - 22 Dec
Crowne Plaza San Diego - Mission Valley by IHG
Crowne Plaza San Diego - Mission Valley by IHGMission Valley
7.8 out of 10, Good, (1007)
"Good value Nice place to stay "
John
The price is AED 342
AED 394 total
includes taxes & fees
21 Dec - 22 Dec
8.2 out of 10, Very Good, (3183)
"Great stay! "
Melissa
The price is AED 411
AED 605 total
includes taxes & fees
5 Jan - 6 January 2026
8.4 out of 10, Very Good, (1311)
"great stay! Food was great and my kids loved the pool and location"
ANDREA
The price is AED 432
AED 662 total
includes taxes & fees
16 Dec - 17 Dec
9.2 out of 10, Wonderful, (1633)
"Nice rooms. Great food at all restaurants "
Steve
8.4 out of 10, Very Good, (1572)
"Loved our stay "
Jeremy
The price is AED 474
AED 739 total
includes taxes & fees
18 Dec - 19 Dec
The DEXTRO Little Italy, BW Premier Collection
The DEXTRO Little Italy, BW Premier CollectionDowntown San Diego
8.8 out of 10, Excellent, (738)
"Friendly staff and clean rooms. "
Justine
The price is AED 379
AED 439 total
includes taxes & fees
28 Dec - 29 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Otay Mesa Hotel Reviews
Hampton Inn & Suites by Hilton San Diego SeaWorld
10/10 Excellent
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