Find Resorts & Hotels with Spas in Otay Mesa, CA

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Otay Mesa Resorts & Hotels with Spas

Our top choices for Otay Mesa hotels with a spa

Fitness studio
Sycuan Casino Resort

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
El Cajon
9.2 out of 10, Wonderful, (1631)
"Nice rooms. Great food at all restaurants "
United States
Steve
Sycuan Casino Resort
Hot stone massages, prenatal massages, sports massages, body scrubs
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1309)
"great stay! Food was great and my kids loved the pool and location"
United States
ANDREA
The price is AED 432
AED 662 total
includes taxes & fees
14 Dec - 15 Dec
San Diego Mission Bay Resort
3 outdoor pools, cabanas (surcharge), pool umbrellas
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1570)
"Loved our stay "
United States
Jeremy
The price is AED 474
AED 739 total
includes taxes & fees
18 Dec - 19 Dec
Hyatt Regency Mission Bay Spa and Marina
Body treatments, aromatherapy, body wraps, body scrubs, facials
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1859)
"Enjoyed my stay"
United States
Brandon
The price is AED 380
AED 621 total
includes taxes & fees
4 Jan - 5 January 2026
Hilton San Diego Bayfront
Exterior
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
Point Loma
8.8 out of 10, Excellent, (1554)
"Every time i have stayed here everything is always clean...no complaints!"
United States
Joseline
The price is AED 420
AED 483 total
includes taxes & fees
4 Jan - 5 January 2026
Best Western Plus Island Palms Hotel & Marina
Couples treatment rooms, sauna, hot tub, steam room, body treatments
Loews Coronado Bay Resort

Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
Silver Strand
8.8 out of 10, Excellent, (1067)
"My stay was wonderful! "
United States
Jeanine
The price is AED 657
AED 908 total
includes taxes & fees
14 Dec - 15 Dec
Loews Coronado Bay Resort
Water view
Kona Kai San Diego

Kona Kai San Diego

Kona Kai San Diego
4.0 star property
Point Loma
8.2 out of 10, Very Good, (1000)
"had a wonderful time for our honey moon here "
United States
Anna
The price is AED 553
AED 856 total
includes taxes & fees
10 Jan - 11 January 2026
Kona Kai San Diego
Front of property - evening/night
Handlery Hotel

Handlery Hotel

Handlery Hotel
3.5 star property
Mission Valley
8.2 out of 10, Very Good, (2228)
"Staff was amazing and very accommodating. Always recommended staying here. "
United States
Taja
Handlery Hotel
Facials, 2 treatment rooms, massages
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1061)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is AED 497
AED 682 total
includes taxes & fees
19 Dec - 20 Dec
The Westin San Diego Bayview
Couples treatment rooms, body treatments, hot stone massages
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
Mission Valley
9.2 out of 10, Wonderful, (2947)
"Friendly, staff was very helpful, great size rooms, and over all was an amazing stay"
United States
Naya
The price is AED 559
AED 642 total
includes taxes & fees
14 Dec - 15 Dec
Legacy Resort Hotel & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Otay Mesa Hotel Reviews

Sheraton San Diego Resort

Sheraton San Diego Resort

10/10 Excellent
"excellent hotel pre-cruise. great appetizers at Happy Hour! Very nice room."
Patricia 1-night trip
Posted 2 days ago
Sheraton San Diego Resort

Explore a world of travel with Expedia

Frequently asked questions

Looking for a spa hotel in Otay Mesa?
Treat yourself to some pampering and book a hotel with a spa. Check out the theater scene and shopping in Otay Mesa—your day trip starts here. Discover the beaches and many popular restaurants during your stay. Hotels with spas are the perfect way to break away from your daily routine and add a layer of luxury to your holiday.
What's there to see and do in Otay Mesa?
Enjoy Otay Mesa with a stop at San Diego Zoo, San Ysidro Border Crossing, and Petco Park. If you have spare time during your trip, you might want to make a stop at Port of San Diego and High Performance Center in Tijuana.
What is a Otay Mesa spa hotel?
Spa hotels in Otay Mesa provide lodging and have a full on-site spa which offers services like massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.