Find Resorts & Hotels with Spas in St. Charles, MO

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Check prices for these dates

Tonight
9 Nov - 10 Nov
Tomorrow
10 Nov - 11 Nov
This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

Our top choices for St. Charles hotels with a spa

A modern spa with a curved reception desk, a large mirror, and a decorative water feature.

1. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.6 out of 10, Excellent, (1,094 reviews)
  • cleanliness
    Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
The price is AED 585
AED 744 total
includes taxes & fees
23 Nov - 24 Nov
Ameristar Casino Resort and Spa
A well-lit lobby with a chandelier, potted plants, and a seating area.

2. Truitt Hotel

Truitt Hotel
2.0 star property
Lafayette Square
9.8 out of 10, Exceptional, (30 reviews)
The price is AED 617
AED 749 total
includes taxes & fees
11 Nov - 12 Nov
Truitt Hotel
A reception desk with a wooden finish and the name "IDOL WOLF" on it.

3. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (2,148 reviews)
  • cleanliness
    Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
The price is AED 526
AED 633 total
includes taxes & fees
15 Nov - 16 Nov
21C Museum Hotel St Louis
A couple relaxing by a window overlooking a bridge and water.

4. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
The price is AED 1,377
AED 1,611 total
includes taxes & fees
10 Nov - 11 Nov
Four Seasons Hotel St Louis
A modern kitchen with wooden cabinets, a central island, and framed artwork on the walls.

5. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (588 reviews)
  • cleanliness
    Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
The price is AED 2,053
AED 2,397 total
includes taxes & fees
27 Nov - 28 Nov
The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in St. Charles

Pool
Hot tub

Top St. Charles Hotel Reviews

A modern spa with a curved reception desk, a large mirror, and a decorative water feature.
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles

10/10 Excellent

The property was very clean, the staff was pleasant and I’m already considering booking again for September!
United States
Quintina
Reviewed July 19, 2025
Ameristar Casino Resort and Spa

Frequently Asked Questions

Looking for a spa hotel in St. Charles?

Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers highly recommend the restaurants in St. Charles. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your daily routine and add a layer of luxury to your vacation.

What is the best spa hotel in St. Charles?

Ameristar Casino Resort and Spa is a top luxury spa hotel featuring 6 restaurants, a casino, a 24-hour fitness center, and an outdoor pool. Treat yourself to a facial, body scrub, or hydrotherapy at Ara.

How many spa hotels will I find in St. Charles?

Among Expedia's 178 accommodation options in St. Charles, there is 1 spa hotel.

What's there to see and do in St. Charles?

Experience all that St. Charles has to offer when you visit Historic Main Street, Katy Trail, and Lewis & Clark Boathouse and Nature Center. If you have some spare time during your trip, you might want to check out St Charles Convention Center and Ameristar Casino St. Charles.

What is a St. Charles spa hotel?

Spa hotels in St. Charles provide lodging and have an on-site spa which offers services like couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

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