A bridge over a turquoise waterfront with boats docked, surrounded by historic buildings.

Find hotels in Santa Lucia, Syracuse

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Lucia hotels

A historic building with ornate balconies, a grand entrance, and flags of the European Union and Italy.

1. Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (708 reviews)
"We enjoyed our stay"
United States
Anna
The price is AED 277
AED 316 total
includes taxes & fees
15 Nov - 16 Nov
Grande Albergo Alfeo
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.

2. Caportigia Boutique Hotel

Caportigia Boutique Hotel
5.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (300 reviews)
"Staff was very friendly and helpful"
Canada
Dena
The price is AED 505
AED 597 total
includes taxes & fees
16 Nov - 17 Nov
Caportigia Boutique Hotel
A modern hotel room with a flat-screen TV mounted on a dark wall, a white desk with a remote control, a bed with a black and white patterned bedspread, and a window with curtains.

3. Nostos rooms & Apartments

Nostos rooms & Apartments
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (295 reviews)
"A really nice room, the bed was extremely comfortable and the staff were very friendly."
United Kingdom
Michael
The price is AED 205
AED 234 total
includes taxes & fees
16 Nov - 17 Nov
Nostos rooms & Apartments
A balcony with wicker chairs and a glass table overlooking a marina with boats.

4. Fortaleza Charme House

Fortaleza Charme House
Santa Lucia
10.0 out of 10, Exceptional, (45 reviews)
"Beautiful accomodation, perfect location close to restauranys and attractions, clean room/all renovated with style, friendly personnel, nice view of the port"
Canada
Martine
The price is AED 588
AED 670 total
includes taxes & fees
16 Nov - 17 Nov
Fortaleza Charme House
A hotel room with a large bed, a chair, a small table, and a chandelier.

5. Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri
4.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (49 reviews)
"Good central location & nice breakfast selection "
Australia
Alan
The price is AED 332
AED 379 total
includes taxes & fees
29 Oct - 30 Oct
Hotel Palazzo Cavalieri
A neatly made bed with a dark quilt, white pillows, and a beige headboard. There are two bedside lamps on either side of the bed.

6. Melody rooms

Melody rooms
Santa Lucia
10.0 out of 10, Exceptional, (1 review)
The price is AED 139
AED 158 total
includes taxes & fees
16 Nov - 17 Nov
Melody rooms
A balcony with a table set for two, a chair, and a view of a building with multiple windows and balconies.

7. B&B Nike

B&B Nike
Santa Lucia
9.0 out of 10, Wonderful, (93 reviews)
"The room and bathroom were large and clean. The mattress and sheets were fantastic. The room had air conditioning. The host was there at check in and was easily accessible. The location was great- just outside Ortigia. Parking was easy and close. An overall nice place to stay."
Canada
Chris
The price is AED 264
AED 301 total
includes taxes & fees
16 Nov - 17 Nov
B&B Nike
A room with a table and chairs, a view of a harbor with boats and buildings, and a clear sky.

8. Lakkios

Lakkios
3.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (81 reviews)
"The location of this place is amazing and that balcony view iconic. Staff super helpful too."
Canada
Marsel
The price is AED 337
AED 384 total
includes taxes & fees
5 Nov - 6 Nov
Lakkios
A terrace with white tables and chairs, white umbrellas, and a view of the sea.

9. Giuggiulena Villa

Giuggiulena Villa
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (134 reviews)
"We had an amazing time. Sabrina and Claudia were wonderful. The place is top notch in everything they do. The food was so fresh and delicious . I was sad when i had to leave them. High praise for this hotel. The views breath taking."
United States
Duane
The price is AED 767
AED 885 total
includes taxes & fees
6 Nov - 7 Nov
Giuggiulena Villa
A marina with numerous boats docked, a clear sky, and a building with outdoor seating.

10. Regina Margherita

Regina Margherita
Santa Lucia
7.8 out of 10, Good, (21 reviews)
"The area is so close to the Ortigia Island where the beautiful cathedral and Doumo are. Lovely walk around the entire island and areas to go in the water If you like. Many dining options and shopping too. Wonderful area!"
United States
Laura
The price is AED 197
AED 225 total
includes taxes & fees
16 Nov - 17 Nov
Regina Margherita
An open balcony with a table and chairs, potted plants, and a view of a building with balconies and windows.

11. Calafatari B&B

Calafatari B&B
3.0 star property
Santa Lucia
9.8 out of 10, Exceptional, (18 reviews)
"Clean, very convenient for exploring Ortigia. Nice continental breakfast."
United States
Mary
The price is AED 494
AED 564 total
includes taxes & fees
4 Nov - 5 Nov
Calafatari B&B
A table with two wine glasses and a decorative item, viewed through a window overlooking a parking area with cars and greenery.

12. Gymnasium

Gymnasium
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (44 reviews)
"Nice kitchen area, centrally located."
United States
Richard
The price is AED 206
AED 235 total
includes taxes & fees
16 Nov - 17 Nov
Gymnasium
An outdoor café with tables and chairs, a bar sign, and a restaurant sign.

13. Residence Agatocle

Residence Agatocle
Santa Lucia
8.8 out of 10, Excellent, (9 reviews)
"This was a perfect apartment for Siracusa and Ortiga. It was massive and the balcony was amazing - but the chairs were a little uncomfortable. I would highly recommend this apartment for a short or long stay"
United Kingdom
Janet
The price is AED 235
AED 349 total
includes taxes & fees
3 Nov - 4 Nov
Residence Agatocle
A hot tub with a view of a marina.

14. Casa Miranda Boutique

Casa Miranda Boutique
Santa Lucia
8.8 out of 10, Excellent, (3 reviews)
"This was one of the best hotel stays I’ve ever had. Simply, you won’t be disappointed from location, excellent service and the most helpful and welcoming staffs. Highly recommended"
United States
Hossein
The price is AED 712
AED 824 total
includes taxes & fees
9 Nov - 10 Nov
Casa Miranda Boutique
A balcony with potted plants and a metal railing.

15. Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia
3.0 star property
Santa Lucia
8.6 out of 10, Excellent, (388 reviews)
"Very old fashioned,poor shower,no coat hangers in wardrobe and no drawers. Hard bed,basic breakfast.Good location and quiet in hotel."
United Kingdom
PETER
The price is AED 299
AED 341 total
includes taxes & fees
28 Oct - 29 Oct
Piccolo Hotel Casa Mia
A modern dining area with a white table, green chairs, and a potted plant.

16. San Nicola Rooms Siracusa

San Nicola Rooms Siracusa
Santa Lucia
8.8 out of 10, Excellent, (15 reviews)
"The breakfast was great! The hosts were super friendly and helpful!"
United States
Lin
The price is AED 427
AED 487 total
includes taxes & fees
16 Nov - 17 Nov
San Nicola Rooms Siracusa
A multi-story building with balconies, a visible 'MOTORSUD' sign, and a 'PIAGGO' sign.

17. Syraka Design Rooms & Suites

Syraka Design Rooms & Suites
Santa Lucia
The price is AED 369
AED 420 total
includes taxes & fees
2 Nov - 3 Nov
Syraka Design Rooms & Suites
A modern bedroom with a bed, bedside table, and a unique feature of a table with a fire effect.

18. B&B IL MORO

B&B IL MORO
Santa Lucia
4.0 out of 10, (1 review)
"Personne sur place pour nous aider. La carte de la chambre était défectueuse dès l'arrivée. Par la suite l'électricité a manqué à 21h, nous avons du contacter les propriétaires via What's App dans le noir. Nous apprécions faire affaire avec des humains et non des applications impersonnelles et des vidéos. Le lit était petit et inconfortable. Pas d'oreiller d'extra ni de boîte de mouchoirs. Le quartier est lugubre."
Canada
Celine B. La
The price is AED 229
AED 355 total
includes taxes & fees
19 Oct - 20 Oct
B&B IL MORO
A rooftop lounge area with lounge chairs and a large potted plant.

19. Le Camere Luxsury Rooms

Le Camere Luxsury Rooms
Santa Lucia
7.0 out of 10, Good, (2 reviews)
"Très belle chambre, mais forte odeur d’humidité, pas de FENÊTRE quartier type « cour des Miracles «  loin du centre historique, pas de supérette ou de restaurant dans le proche voisinage loin de toute commodité"
France
Philippe
The price is AED 183
AED 303 total
includes taxes & fees
20 Oct - 21 Oct
Le Camere Luxsury Rooms
A hotel room with a bed, a view of the sea, and a small table with a chair.

20. Eos Sea View Apartment

Eos Sea View Apartment
Santa Lucia
10.0 out of 10, Exceptional, (2 reviews)
"Great location and clean apartment."
United States
Siarhei
The price is AED 773
AED 998 total
includes taxes & fees
16 Nov - 17 Nov
Eos Sea View Apartment
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Lucia

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A terrace with white tables and chairs, white umbrellas, and a view of the sea.
Giuggiulena Villa
3.0 star property
10.0
Exceptional
134 reviews
View
A room with a table and chairs, a view of a harbor with boats and buildings, and a clear sky.
Lakkios
3.0 star property
9.2
Wonderful
81 reviews
View
A hotel room with a large bed, a chair, a small table, and a chandelier.
Hotel Palazzo Cavalieri
4.0 star property
9.0
Wonderful
49 reviews
View
A modern hotel room with a flat-screen TV mounted on a dark wall, a white desk with a remote control, a bed with a black and white patterned bedspread, and a window with curtains.
Nostos rooms & Apartments
3.0 star property
9.0
Wonderful
295 reviews
View
A table with two wine glasses and a decorative item, viewed through a window overlooking a parking area with cars and greenery.
Gymnasium
3.0 star property
8.8
Excellent
44 reviews
View

Hotels recommended for families in Santa Lucia

A historic building with ornate balconies, a grand entrance, and flags of the European Union and Italy.

Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (708)
The price is AED 277
AED 316 total
includes taxes & fees
15 Nov - 16 Nov
Grande Albergo Alfeo

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most.
A historic waterfront with a stone bridge, illuminated buildings, and a calm water body.

Ortigia

Travelers come to Ortigia for its seaside views, and you can see top attractions like Cathedral of Syracuse and Piazza del Duomo while you're in town.

Ancient ruins with a large amphitheater surrounded by trees.
Photo by William Keller
Open Photo by William Keller

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

A natural rock arch over a body of water with people paddling in kayaks.
Photo by Salvo Cannizzaro
Open Photo by Salvo Cannizzaro

Grottasanta

Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood.

An aerial view of a coastal city with a prominent fortified structure and a densely built urban area in the background.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

Top Santa Lucia Hotel Reviews

Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

10/10 Excellent
"Great boutique hotel in perfect location with amazing staff"
Claudio 1-night trip
Posted 2 days ago
Algila' Ortigia Charme Hotel

Frequently asked questions

What is Santa Lucia like?
Santa Lucia is a neighborhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Be sure to check out Porto Piccolo and Ionian Sea while you're in the neighborhood.
Where is the best place to stay in Santa Lucia?
Based on our traveler data, Grande Albergo Alfeo is one of the top choices for your stay in Santa Lucia. This hotel offers free breakfast and a restaurant. Other good choices for your stay in the area include Nostos rooms & Apartments and Caportigia Boutique Hotel.
How many hotels can I expect to find in Santa Lucia?
Expedia has 313 hotels and other accommodations in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.
If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get the best options available in Santa Lucia.
Where can I learn more about changing or cancelling my trip to Santa Lucia?
For more details about changing or cancelling your trip to Santa Lucia, click here.
What are the top things to see and do in Santa Lucia?
Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops to visit in the neighborhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica, and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.