Find Resorts & Hotels with Spas in Texas Medical Center, TX

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Texas Medical Center Resorts & Hotels with Spas

Our top choices for Texas Medical Center hotels with a spa

Body treatments, deep-tissue massages, Swedish massages
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center
9.0 out of 10, Wonderful, (3608)
"Everything about our stay was excellent. "
United States
Clarence
The price is AED 484
AED 566 total
includes taxes & fees
15 Jan - 16 January 2026
Blossom Hotel Houston, Curio Collection by Hilton
Body treatments, hot stone massages, deep-tissue massages
Hilton Americas-Houston

Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
Downtown Houston
9.4 out of 10, Exceptional, (1602)
"Great hotel. Lively bar, great breakfast, friendly staff, nice room, close to everything. "
United States
Thomas
The price is AED 503
AED 595 total
includes taxes & fees
1 Jan - 2 January 2026
Hilton Americas-Houston
Couples treatment rooms, sauna, hot tub, body treatments, hydrotherapy
Omni Houston Hotel

Omni Houston Hotel

Omni Houston Hotel
4.0 star property
Greater Uptown
9.0 out of 10, Wonderful, (1008)
"A great place to stay "
United States
Juan
The price is AED 585
AED 694 total
includes taxes & fees
16 Dec - 17 Dec
Omni Houston Hotel
Reception
JW Marriott Houston Downtown

JW Marriott Houston Downtown

JW Marriott Houston Downtown
5.0 star property
Downtown Houston
9.0 out of 10, Wonderful, (1002)
"Love the room very kind personal at the check in. "
United States
Antonia
The price is AED 702
AED 847 total
includes taxes & fees
19 Dec - 20 Dec
JW Marriott Houston Downtown
Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe
The Laura Hotel, Houston Downtown, Autograph Collection

The Laura Hotel, Houston Downtown, Autograph Collection

The Laura Hotel, Houston Downtown, Autograph Collection
4.5 star property
Downtown Houston
9.0 out of 10, Wonderful, (1040)
"The Laura is a great hotel. The amenities, restaurants and bar are top notch. The staff was friendly, helpful and knowledgable about the services offered by the hotel and offered great suggestions for nearby restaurants and entertainment. I enjoyed my stay. No complaints. "
United States
Seleta
The price is AED 569
AED 781 total
includes taxes & fees
17 Dec - 18 Dec
The Laura Hotel, Houston Downtown, Autograph Collection
Couples treatment rooms, hot tub, body treatments, deep-tissue massages
Marriott Marquis Houston

Marriott Marquis Houston

Marriott Marquis Houston
4.0 star property
Downtown Houston
9.0 out of 10, Wonderful, (1012)
"Completely loved our stay at this location. "
United States
Miriam
The price is AED 797
AED 1,036 total
includes taxes & fees
1 Jan - 2 January 2026
Marriott Marquis Houston
Body treatments, aromatherapy, body scrubs, facials
Four Seasons Hotel Houston

Four Seasons Hotel Houston

Four Seasons Hotel Houston
5.0 star property
Downtown Houston
9.2 out of 10, Wonderful, (1002)
"Room was clean"
United States
Kimberly
The price is AED 1,634
AED 1,931 total
includes taxes & fees
7 Jan - 8 January 2026
Four Seasons Hotel Houston
Sauna
Hotel ZaZa Houston Memorial City

Hotel ZaZa Houston Memorial City

Hotel ZaZa Houston Memorial City
4.0 star property
Memorial
9.4 out of 10, Exceptional, (1005)
"Beautiful hotel, amazing customer service and it was so comfy. "
United States
Amber
The price is AED 2,781
AED 3,464 total
includes taxes & fees
13 Jan - 14 January 2026
Hotel ZaZa Houston Memorial City
Sauna, body treatments, hydrotherapy, aromatherapy, body wraps
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1848)
"Very nice room, great staff, excellent food & drink."
United States
Mary
Hotel Zaza Houston Museum District
Couples treatment rooms, hot tub, steam room, body treatments
The Houstonian Hotel, Club & Spa

The Houstonian Hotel, Club & Spa

The Houstonian Hotel, Club & Spa
4.5 star property
Greater Uptown
9.4 out of 10, Exceptional, (1000)
"Excellent hotel in every way."
United States
John
The price is AED 1,749
AED 2,057 total
includes taxes & fees
18 Dec - 19 Dec
The Houstonian Hotel, Club & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Texas Medical Center Hotel Reviews

Hilton Americas-Houston

Hilton Americas-Houston

10/10 Excellent
"The room was clean and comfortable. Service was excellent."
Gus 1-night trip
Posted 2 days ago
Hilton Americas-Houston

Explore a world of travel with Expedia

Frequently asked questions

Looking to vacation at a spa hotel in Texas Medical Center?
Forget the stress of everyday life and book yourself a lush spa hotel. Check out the museums and restaurants in Texas Medical Center—your day trip starts here. Be sure to enjoy the shopping during your stay. Spa hotels are a great way to break away from your daily routine and add a layer of luxury to your vacation.
What is the best spa hotel in Texas Medical Center?
Blossom Hotel Houston, Curio Collection by Hilton is a top spa hotel featuring a rooftop terrace, a 24-hour fitness center, an outdoor pool, and a restaurant. Spend an afternoon at the spa where you'll find facials, Swedish massages, and deep-tissue massages.
How many spa hotels are there in Texas Medical Center?
Among Expedia's 184 accommodation options in Texas Medical Center, there is 1 spa hotel.
What's there to see and do in Texas Medical Center?
Enjoy all that Texas Medical Center has to offer when you visit Houston Zoo, NRG Stadium, and Houston Natural Science Museum. If you have extra time while you're in the area, you might want to stop by NRG Astrodome and NRG Park.
What is a Texas Medical Center spa hotel?
Spa hotels in Texas Medical Center have full on-site spas offering services like couples massages and a selection of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are ideal if you are looking for some R&R during your vacation.