A modern building with a unique triangular roof and a central spire.

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Check prices for these dates

Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

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Our top choices for Santa Lucia hotels

A historic building with ornate balconies, a grand entrance, and flags of the European Union and Italy.

1. Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (708 reviews)
"We enjoyed our stay"
United States
Anna
Grande Albergo Alfeo
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.

2. Caportigia Boutique Hotel

Caportigia Boutique Hotel
5.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (300 reviews)
"Staff was very friendly and helpful"
Canada
Dena
Caportigia Boutique Hotel
A modern hotel room with a flat-screen TV mounted on a dark wall, a white desk with a remote control, a bed with a black and white patterned bedspread, and a window with curtains.

3. Nostos rooms & Apartments

Nostos rooms & Apartments
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (295 reviews)
"A really nice room, the bed was extremely comfortable and the staff were very friendly."
United Kingdom
Michael
Nostos rooms & Apartments
A hotel room with a large bed, a chair, a small table, and a chandelier.

4. Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri
4.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (48 reviews)
"Good central location & nice breakfast selection "
Australia
Alan
Hotel Palazzo Cavalieri
A balcony with wicker chairs and a glass table overlooking a marina with boats.

5. Fortaleza Charme House

Fortaleza Charme House
Santa Lucia
10.0 out of 10, Exceptional, (44 reviews)
"Beautiful accomodation, perfect location close to restauranys and attractions, clean room/all renovated with style, friendly personnel, nice view of the port"
Canada
Martine
Fortaleza Charme House
A room with a table and chairs, a view of a harbor with boats and buildings, and a clear sky.

6. Lakkios

Lakkios
3.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (80 reviews)
"The location of this place is amazing and that balcony view iconic. Staff super helpful too."
Canada
Marsel
Lakkios
A neatly made bed with a dark quilt, white pillows, and a beige headboard. There are two bedside lamps on either side of the bed.

7. Melody rooms

Melody rooms
Santa Lucia
10.0 out of 10, Exceptional, (1 review)
Melody rooms
A balcony with a table set for two, a chair, and a view of a building with multiple windows and balconies.

8. B&B Nike

B&B Nike
Santa Lucia
9.0 out of 10, Wonderful, (93 reviews)
"The room and bathroom were large and clean. The mattress and sheets were fantastic. The room had air conditioning. The host was there at check in and was easily accessible. The location was great- just outside Ortigia. Parking was easy and close. An overall nice place to stay."
Canada
Chris
B&B Nike
A terrace with white tables and chairs, white umbrellas, and a view of the sea.

9. Giuggiulena Villa

Giuggiulena Villa
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (132 reviews)
"We had an amazing time. Sabrina and Claudia were wonderful. The place is top notch in everything they do. The food was so fresh and delicious . I was sad when i had to leave them. High praise for this hotel. The views breath taking."
United States
Duane
Giuggiulena Villa
A hotel room with a bed, a desk with a lamp, a television, a wardrobe, and a painting on the wall.

10. Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia
3.0 star property
Santa Lucia
8.6 out of 10, Excellent, (388 reviews)
"Very old fashioned,poor shower,no coat hangers in wardrobe and no drawers. Hard bed,basic breakfast.Good location and quiet in hotel."
United Kingdom
PETER
Piccolo Hotel Casa Mia
An outdoor café with tables and chairs, a bar sign, and a restaurant sign.

11. Residence Agatocle

Residence Agatocle
Santa Lucia
8.8 out of 10, Excellent, (9 reviews)
"This was a perfect apartment for Siracusa and Ortiga. It was massive and the balcony was amazing - but the chairs were a little uncomfortable. I would highly recommend this apartment for a short or long stay"
United Kingdom
Janet
Residence Agatocle
A marina with numerous boats docked, a clear sky, and a building with outdoor seating.

12. Regina Margherita

Regina Margherita
Santa Lucia
7.8 out of 10, Good, (21 reviews)
"The area is so close to the Ortigia Island where the beautiful cathedral and Doumo are. Lovely walk around the entire island and areas to go in the water If you like. Many dining options and shopping too. Wonderful area!"
United States
Laura
Regina Margherita
A table with two wine glasses and a decorative item, viewed through a window overlooking a parking area with cars and greenery.

13. Gymnasium

Gymnasium
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (43 reviews)
"Nice kitchen area, centrally located."
United States
Richard
Gymnasium
A living room with a brown armchair, a sofa with patterned cushions, a glass coffee table with a bottle and glasses, and a fruit basket.

14. Syraka Design Rooms & Suites

Syraka Design Rooms & Suites
Santa Lucia
Syraka Design Rooms & Suites
An open balcony with a table and chairs, potted plants, and a view of a building with balconies and windows.

15. Calafatari B&B

Calafatari B&B
3.0 star property
Santa Lucia
9.8 out of 10, Exceptional, (18 reviews)
"Clean, very convenient for exploring Ortigia. Nice continental breakfast."
United States
Mary
Calafatari B&B
A hot tub with a view of a marina.

16. Casa Miranda Boutique

Casa Miranda Boutique
Santa Lucia
8.8 out of 10, Excellent, (3 reviews)
"This was one of the best hotel stays I’ve ever had. Simply, you won’t be disappointed from location, excellent service and the most helpful and welcoming staffs. Highly recommended"
United States
Hossein
Casa Miranda Boutique
A modern bedroom with a bed, bedside table, and a unique feature of a table with a fire effect.

17. B&B IL MORO

B&B IL MORO
Santa Lucia
4.0 out of 10, (1 review)
"Personne sur place pour nous aider. La carte de la chambre était défectueuse dès l'arrivée. Par la suite l'électricité a manqué à 21h, nous avons du contacter les propriétaires via What's App dans le noir. Nous apprécions faire affaire avec des humains et non des applications impersonnelles et des vidéos. Le lit était petit et inconfortable. Pas d'oreiller d'extra ni de boîte de mouchoirs. Le quartier est lugubre."
Canada
Celine B. La
B&B IL MORO
A modern dining area with a white table, green chairs, and a potted plant.

18. San Nicola Rooms Siracusa

San Nicola Rooms Siracusa
Santa Lucia
8.8 out of 10, Excellent, (13 reviews)
"The breakfast was great! The hosts were super friendly and helpful!"
United States
Lin
San Nicola Rooms Siracusa
A woman in a black swimsuit sitting in a hot tub overlooking a beach with a clear sky and the sun shining.

19. Re Dionisio Luxury Suites

Re Dionisio Luxury Suites
3.0 star property
Santa Lucia
8.6 out of 10, Excellent, (59 reviews)
"Wonderful property, excellent staff and the most amazing view from the apartment"
Australia
Anthony
Re Dionisio Luxury Suites
A rooftop lounge area with lounge chairs and a large potted plant.

20. Le Camere Luxsury Rooms

Le Camere Luxsury Rooms
Santa Lucia
7.0 out of 10, Good, (2 reviews)
"Très belle chambre, mais forte odeur d’humidité, pas de FENÊTRE quartier type « cour des Miracles «  loin du centre historique, pas de supérette ou de restaurant dans le proche voisinage loin de toute commodité"
France
Philippe
Le Camere Luxsury Rooms
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Lucia

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A terrace with white tables and chairs, white umbrellas, and a view of the sea.
Giuggiulena Villa
3.0 star property
10.0
Exceptional
132 reviews
View
A room with a table and chairs, a view of a harbor with boats and buildings, and a clear sky.
Lakkios
3.0 star property
9.2
Wonderful
80 reviews
View
A modern hotel room with a flat-screen TV mounted on a dark wall, a white desk with a remote control, a bed with a black and white patterned bedspread, and a window with curtains.
Nostos rooms & Apartments
3.0 star property
9.0
Wonderful
295 reviews
View
A hotel room with a large bed, a chair, a small table, and a chandelier.
Hotel Palazzo Cavalieri
4.0 star property
9.0
Wonderful
48 reviews
View
A table with two wine glasses and a decorative item, viewed through a window overlooking a parking area with cars and greenery.
Gymnasium
3.0 star property
8.8
Excellent
43 reviews
View

Hotels recommended for families in Santa Lucia

A historic building with ornate balconies, a grand entrance, and flags of the European Union and Italy.

Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (708)
Grande Albergo Alfeo

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most.
A historic waterfront with a stone bridge, illuminated buildings, and a calm water body.

Ortigia

Travelers come to Ortigia for its seaside views, and you can see top attractions like Cathedral of Syracuse and Piazza del Duomo while you're in town.

Ancient ruins with a large amphitheater surrounded by trees.
Photo by William Keller
Open Photo by William Keller

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

A natural rock arch over a body of water with people paddling in kayaks.
Photo by Salvo Cannizzaro
Open Photo by Salvo Cannizzaro

Grottasanta

Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood.

An aerial view of a coastal city with a prominent fortified structure and a densely built urban area in the background.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

Top Santa Lucia Hotel Reviews

Lanterne Magiche Ortigia

Lanterne Magiche Ortigia

10/10 Excellent
"Great location and a nice spacious apartment. Breakfast was rather poor - very basic spread with heavy emphasis on pastries"
Anil 2-night trip
Posted 16 hours ago
Lanterne Magiche Ortigia

Frequently asked questions

What is Santa Lucia like?
Santa Lucia is a neighborhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Be sure to check out Porto Piccolo and Ionian Sea while you're in the neighborhood.
Where is the best place to stay in Santa Lucia?
Based on our traveler data, Grande Albergo Alfeo is one of the top choices for your stay in Santa Lucia. This hotel offers free breakfast and a restaurant. Other good choices for your stay in the area include Nostos rooms & Apartments and Caportigia Boutique Hotel.
How many hotels can I expect to find in Santa Lucia?
Expedia has 313 hotels and other accommodations in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.
If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get the best options available in Santa Lucia.
Where can I learn more about changing or cancelling my trip to Santa Lucia?
For more details about changing or cancelling your trip to Santa Lucia, click here.
What are the top things to see and do in Santa Lucia?
Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops to visit in the neighborhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica, and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.