Top Vacation Homes in Perry County in 2026

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Our top choices for Perry County vacation homes

A spacious living room with a brick wall, wooden beams, a black leather sofa, a wooden coffee table, and a dining area with a table and chairs.

1. * On the Wine Trail * Hot Tub * Wi-Fi *

Alto Pass

scott

A hallway with wooden flooring leading to a dining area with a table and chairs.

2. 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

Cape Girardeau

Tracy H.

A dining area with a round wooden table, white chairs, a vase with flowers, and a view through large windows.

3. “Kozy on Kingsway” is a charming 4-bedroom house in Cape -The City of Roses

Cape Girardeau

Merry J.

A single-story house with a front porch, a mailbox, and a small garden area.

4. Cozy Three bedroom home in Central Farmington

Farmington

Theresa

AED 938 total

includes taxes & fees

15 Oct - 16 Oct

A compact living space with a sofa set, a dining table, and a kitchenette.

5. * Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

Alto Pass

Cory G.

A wooden desk with a chair, a desk lamp, and a small white box labeled "HOME" on the wall.

6. Cozy and Updated Farmhouse with King Suite

Anna

Kathy H.

AED 580 total

includes taxes & fees

19 Oct - 20 Oct

A reception desk with a 'STAY awhile' sign, a welcome sign, and a guest book.

7. Cozy Haven Our Little Gem Sleeps 4

Ste.Genevieve

Alexis A.

A two-story house with a porch, a welcome sign, and a flag.

8. Doves Nest Guest House<br> Tranquil & Relaxing

Ste. Genevieve

Kate G.

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Top Perry County Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"They serve an amazing happy hour and breakfast with à large selection of food. Very nice and comfortable room"

Drury Inn & Suites Jackson MO

8/10 Good

"My room was spacious. The staff was amazing. Everything was well kept and maintained. I didn't like that the toilet in my king deluxe room was very short (low). I'm 5' 4" and husband is 6'. I struggled getting up. I'm sure my husband was very uncomfortable as well! Also, the placement of the luggage carts just beyond the entry doors and registration placed immediately left of same doors with a line of standing people seems like a fire hazard and very inconvenient. I struggled to get pass the area with my loaded luggage cart while avoiding empty luggage carts and nearly colliding with an older gentleman."