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Check availability on Sikeston Casinos

Tonight
4 Dec - 5 Dec
Tomorrow
5 Dec - 6 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Top Sikeston Casinos

Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
Jackson
8.8 out of 10, Excellent, (659)
"Great place "
United States
GUY
The price is AED 287
AED 311 total
includes taxes & fees
4 Jan - 5 January 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (466)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is AED 426
AED 483 total
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott Cape Girardeau Downtown
Lobby sitting area
The Riverview

The Riverview

4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (464)
"Place was nice and safe"
United States
ryan
The price is AED 354
AED 399 total
includes taxes & fees
7 Dec - 8 Dec
The Riverview
Standard Room, 1 Queen Bed, Non Smoking, Garden View | Free WiFi
Rockwood Inn

Rockwood Inn

2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (18)
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
United States
Vanessa
The price is AED 519
AED 585 total
includes taxes & fees
7 Dec - 8 Dec
Rockwood Inn
Fridge, microwave, oven, stovetop
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
United States
Tracy H.
The price is AED 551
AED 900 total
includes taxes & fees
7 Dec - 8 Dec
Serenity South -- Gardens, River-Views, and Refreshing Space
Exterior
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Cape Girardeau
9.6 out of 10, Exceptional, (7)
"Nice place, great times"
United States
Jace W.
The price is AED 988
AED 1,607 total
includes taxes & fees
7 Dec - 8 Dec
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Terrace/patio
Contemporary Glamping with Native American Appeal

Contemporary Glamping with Native American Appeal

Anna
9.8 out of 10, Exceptional, (155)
"Our 2nd time staying here and it was perfect"
United States
machelle p.
The price is AED 551
AED 1,043 total
includes taxes & fees
7 Dec - 8 Dec
Contemporary Glamping with Native American Appeal
Smart TV, fireplace, DVD player
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Anna
10.0 out of 10, Exceptional, (403)
"Very clean, courteus staff. Beautiful area and quiet. Very relaxing."
United States
Tommy
The price is AED 430
AED 743 total
includes taxes & fees
7 Dec - 8 Dec
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Interior
Minutes from Giant City - SIU - Shawnee Winetrail - Cedar Lake - Shawnee Forest!

Minutes from Giant City - SIU - Shawnee Winetrail - Cedar Lake - Shawnee Forest!

Makanda
9.6 out of 10, Exceptional, (47)
"I was very happy with the cleanliness and amenities including Internet access, snacks, bathing, and comfortable sleeping."
United States
Timothy W.
Minutes from Giant City - SIU - Shawnee Winetrail - Cedar Lake - Shawnee Forest!
Exterior
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

Makanda
9.8 out of 10, Exceptional, (60)
"The property was extremely clean and well cared for.would definitely stay again. "
United States
Dan H.
The price is AED 584
AED 738 total
includes taxes & fees
6 Dec - 7 Dec
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Sikeston Hotel Reviews

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

10/10 Excellent
"I liked how comfortable the beds and pillows were."
Christine 4-night trip
Posted 4 days ago
Pear Tree Inn Cape Girardeau Near the Medical Center

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Frequently asked questions

Searching for casino hotels in Sikeston?
Tourists speak highly of the family-friendly activities, shopping, and local cuisine.
How many hotels that are good for gaming can I expect to find in Sikeston?
You won't need a stroke of luck to find something that suits with one of Expedia's 15 casino hotels in Sikeston.
When should I take my casino trip to Sikeston?
You might spend a lot of your vacation inside, but if you want to see more of the area, looking at local weather trends is a good idea. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.
What is there to do in Sikeston?
If you're interested in local cultural spots, you can check out Sikeston Depot Museum and Front Street Studio & Art Gallery. Nature enthusiasts will appreciate the riverfront, and places to get outdoors include Shawnee National Forest, Mississippi River, and Ohio River Valley. If you're looking for more to see and do, you can add Central Park and Stoddard County Civil War Memorial Cemetery to your list.
What are my transportation options for my casino getaway to Sikeston?
Here are some transportation options in Sikeston: You can arrange a flight to the nearest airport, which is Cairo, IL (CIR-Cairo Regional), 23.8 mi (38.3 km) from the city center. If you'd like to explore around the area, you may want a rental car for your journey.