Photo by Ryan Coleman

Find Luxury Hotels in Sikeston, MO

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Sikeston Luxury Hotels

Top Sikeston Luxury Hotels

1 bedroom, desk, laptop workspace, blackout drapes
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2.0 star property
Sikeston
7.2 out of 10, Good, (1001)
"A great stay in every aspect. "
United States
Gertrude
The price is AED 231
AED 263 total
includes taxes & fees
18 Nov - 19 Nov
Days Inn and Suites by Wyndham Sikeston
Property grounds
Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau
10.0 out of 10, Exceptional, (223)
"Property location was perfect.Deck view was great.Very clean and comfortable place."
United States
Robert M.
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Always enjoy our stay. Staff is very friendly, especially at breakfast! "
United States
Paul
The price is AED 257
AED 290 total
includes taxes & fees
20 Nov - 21 Nov
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby
Quality Inn

Quality Inn

2.5 star property
Cape Girardeau
7.2 out of 10, Good, (674)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is AED 231
AED 261 total
includes taxes & fees
14 Dec - 15 Dec
Quality Inn
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
"Clean room, great location and friendly staff"
United States
Mark
The price is AED 353
AED 405 total
includes taxes & fees
20 Nov - 21 Nov
Drury Inn & Suites Sikeston, MO
Business center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"Rooms are nice and big. Breakfast was above average and staff was very nice and friendly. "
United States
Sandra
The price is AED 331
AED 373 total
includes taxes & fees
23 Nov - 24 Nov
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Sikeston Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"This was a wonderful stay! "
Amanda 2-night trip
Posted 4 days ago
Drury Inn & Suites Sikeston, MO

Explore a world of travel with Expedia

Frequently asked questions

Are you looking for a luxury hotel for your stay in Sikeston?
Use Expedia and let us help you arrange a flight to Cairo, IL (CIR-Cairo Regional) airport or Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Sikeston has to offer. During your visit, you might want to enjoy the shopping which Sikeston is known for.
When can I expect good weather in Sikeston?
Planning for the weather is a good way to make your trip to Sikeston relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.
What's there to see and do in Sikeston?
Experience all that Sikeston has to offer when you visit Sikeston Depot Museum, Central Park, and Front Street Studio & Art Gallery. If you have a little extra time during your trip, you might want to make a stop at Stoddard County Civil War Memorial Cemetery and Hunter-Dawson State Historic Site.