Photo by Ryan Coleman
Find 4 Star Hotels in Sikeston, MO
Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Sikeston 4 Star Hotels
Compare Sikeston 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Frequently asked questions
Sikeston Hotels by Star Rating
Stay near popular Sikeston attractions
More Hotel Options in Sikeston
- Adventure Hotels (5)
- Business Hotels (19)
- Casinos (9)
- Cheap Hotels (14)
- Family Hotels (25)
- Golf Hotels (9)
- Historic Hotels (5)
- Hotel Wedding Venues (6)
- Hotels with Bars (9)
- Hotels with Free Parking (27)
- Hotels with Hot Tubs (10)
- Hotels with WiFi (28)
- Hotels with a Pool (19)
- Hotels with an Indoor Pool (13)
- Hotels with smoking rooms (5)
- Luxury Hotels (7)
- Pet-friendly Hotels (24)
- Resorts & Hotels with Spas (5)
- Romantic Hotels (1)
- Shopping Hotels (17)
- Winery Hotels (4)
More Accommodation Types in Sikeston
Explore more hotels
- Auburn Place Hotel And Suites
- Pear Tree Inn Cape Girardeau West
- Drury Plaza Hotel Cape Girardeau Conference Center
- Pear Tree Inn Cape Girardeau Near the Medical Center
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
- Drury Inn & Suites Cape Girardeau
- Candlewood Suites Cape Girardeau, an IHG Hotel
- Courtyard by Marriott Cape Girardeau Downtown
- Quality Inn
- Comfort Suites Jackson-Cape Girardeau
- New cabin in the woods with private hot tub
- Town House Inn
- Holiday Inn Express & Suites Perryville, an IHG Hotel
- Rest, Relax and Renew. Our log cabin experience awaits your arrival.
- Hotel 7 Inn Anna
- Super 8 by Wyndham Perryville
- Hampton Inn Cape Girardeau I 55 East
- Holiday Inn Express & Suites Murphysboro - Carbondale, an IHG Hotel
- Drury Inn & Suites Jackson MO