Find hotels in East Main Street, Grand Junction from AED 220
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Discover 560 East Main Street hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

The Homestead
The Homestead
10.0 out of 10, Exceptional, (42)
The price is AED 789
AED 831 total
includes taxes & fees
10 Jun - 11 Jun

Spoke and Vine Motel
Spoke and Vine Motel
9.8 out of 10, Exceptional, (150)
The price is AED 614
AED 681 total
includes taxes & fees
16 Jun - 17 Jun

Wine Country Inn Palisade
Wine Country Inn Palisade
9.6 out of 10, Exceptional, (1002)

Best Western Grande River Inn & Suites
Best Western Grande River Inn & Suites
9.0 out of 10, Wonderful, (703)
The price is AED 482
AED 508 total
includes taxes & fees
9 Jul - 10 Jul

Motel 6 Grand Junction, CO
Motel 6 Grand Junction, CO
6.2 out of 10, (1003)
The price is AED 220
AED 253 total
includes taxes & fees
10 Jun - 11 Jun

Residence Inn by Marriott Grand Junction
Residence Inn by Marriott Grand Junction
8.8 out of 10, Excellent, (449)
The price is AED 496
AED 569 total
includes taxes & fees
29 Jun - 30 Jun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in East Main Street
Find the best East Main Street areas and neighborhoods for the activities you enjoy most.
Downtown
1 out of top 10 points of interest in this area
While there might not be top attractions in Downtown, you can explore the larger area and discover places like Western Colorado Botanical Gardens and Bananas Fun Park.
Redlands
1 out of top 10 points of interest in this area
You'll enjoy the mountain views and wineries in Redlands. You might want to make time for a stop at Colorado National Monument or Redlands Mesa Golf Club.
Pear Park
If you're spending some time in Pear Park, Colorado River and James M. Robb – Colorado River State Park are top sights worth seeing.
Horizon Drive District
While there might not be top attractions in Horizon Drive District, you can explore the larger area and discover places like Canyon View Park and Bananas Fun Park.
Orchard Mesa
1 out of top 10 points of interest in this area
If you're spending some time in Orchard Mesa, Mesa County Fairgrounds and Gunnison River are top sights worth seeing.
Recent reviews of East Main Street hotels
Recent reviews of East Main Street hotels

Studio 6 Grand Junction, CO
5/5 Excellent
Cheap place but decent
"Slept well. Housekeeping was nice. "
A verified traveler stayed at Studio 6 Grand Junction, CO
Posted 2 days ago
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Hotels near popular Grand Junction Attractions
- Hotels near Colorado Mesa University
- Hotels near Colorado River
- Hotels near Colorado National Monument
- Hotels near Canyon View Park
- Hotels near Two Rivers Convention Center
- Hotels near Redlands Mesa Golf Club
- Hotels near Bananas Fun Park
- Hotels near Mesa County Fairgrounds
- Hotels near Western Colorado Botanical Gardens
- Hotels near Gunnison River
More Accommodation Types in
Hotels Close to Nearby Airports
East Main Street Hotels by Star Rating
East Main Street Hotels by Brand
Explore more hotels
- Red Roof Inn Grand Junction
- Wine Country Inn Palisade
- Super 8 by Wyndham Fruita
- Hotel Maverick
- La Quinta Inn & Suites by Wyndham Fruita
- Courtyard by Marriott Grand Junction
- Holiday Inn and Suites Grand Junction by IHG
- Motel 6 Grand Junction, CO
- Quality Inn Grand Junction near University
- Holiday Inn Express & Suites Grand Junction by IHG
- Best Western Grande River Inn & Suites
- Comfort Inn Grand Junction I-70