Santo Spirito

Florence

Brancacci Chapel which includes heritage architecture, a church or cathedral and a sunset
Brancacci Chapel which includes heritage architecture and a church or cathedral
Brancacci Chapel featuring heritage elements
Brancacci Chapel which includes a church or cathedral and heritage architecture
Arcetri which includes a city and landscape views

Popular places to visit

Piazza Santo Spirito

Piazza Santo Spirito

Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art scene and notable monuments in this vibrant area.

Piazza Santo Spirito
Porta Romana

Porta Romana

Find out about the history of Arcetri when you take a trip to Porta Romana. Amble around this vibrant area's riverfront or experience its fascinating museums.

Porta Romana
Brancacci Chapel which includes heritage architecture and a church or cathedral

Brancacci Chapel

You can learn about the history of Florence with a stop at Brancacci Chapel. Stroll along the riverfront or visit the stunning cathedral in this vibrant area.

Brancacci Chapel
Uffizi Gallery

Uffizi Gallery

Uffizi Gallery is a top museum in Florence with a rich history. Stroll along the riverfront or visit the churches in this vibrant area.

Uffizi Gallery
Ponte Vecchio which includes a bridge and a river or creek

Ponte Vecchio

Ponte Vecchio is just one of the places to see in Florence, so why not enjoy the other things to explore during your travels? Visit the stunning cathedral and notable monuments in this vibrant area.

Ponte Vecchio
Cathedral of Santa Maria del Fiore featuring a city, heritage architecture and a church or cathedral

Cathedral of Santa Maria del Fiore

Find out about the history of Cathedral of Santa Maria del Fiore, a well-known monument in Florence. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Cathedral of Santa Maria del Fiore

Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13, Florence, FI
The price is AED 525 per night from Nov 2 to Nov 3
AED 525
AED 638 total
2 Nov - 3 Nov
includes taxes & fees
Stay at this 4-star hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.6/10 Exceptional! (568 reviews)
"I thought it was great but the wife didn’t think it was completely worthy of 5 stars. She’s hard to please."

Reviewed on 30 September 2025

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r, Florence, FI
Stay at this 4-star residence in Florence. Enjoy free WiFi, concierge services, and satellite TV channels. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,033 reviews)
"The apartment is beautiful, quite large (especially by European standards), very clean, and centrally located in the Santo Spirito, and only about a 5-minute walk to Ponte Vecchio. The people at reception were all very friendly and helpful. We would definitely stay here again when in Florence."

Reviewed on 30 September 2025

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Palazzo Mannaioni Suites
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59, Florence, FI
The price is AED 761 per night from Oct 5 to Oct 6
AED 761
AED 897 total
5 Oct - 6 Oct
includes taxes & fees
Stay at this 4-star boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (990 reviews)
"Amazing place, love the decor!"

Reviewed on 28 July 2025

UNA Hotels Vittoria Firenze
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8, Florence, FI
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Ponte Vecchio and Uffizi Gallery ...
9/10 Wonderful! (211 reviews)
"Beautiful hotel in a great location! Staff was super friendly and helpful and the price is a bargain compared to some other hotels. We had a great experience!"

Reviewed on 25 September 2025

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La Torre Del Cestello
Casa Santo Nome di Gesù

Casa Santo Nome di Gesù

Piazza del Carmine, 21, Florence, FI
Stay at this guesthouse in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (328 reviews)
"Solo woman traveler here. Felt very safe. Loved the convenience and options of breakfast every morning. The garden is lovely and wished I had spent more time there. The room was nothing fancy, but my time there was great. Thankfully nobody was staying next door to my room because the last night I ..."

Reviewed on 26 September 2025

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Casa Santo Nome di Gesù
Hotel Firenze 2000

Hotel Firenze 2000

2 out of 5
Viale Raffaello Sanzio, 16, Florence, FI
The price is AED 408 per night from Oct 12 to Oct 13
AED 408
AED 487 total
12 Oct - 13 Oct
includes taxes & fees
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Popular attractions Ponte Vecchio and Uffizi Gallery are located ...
7.2/10 Good! (178 reviews)
"The breakfast was great and the room was spacious. Transit in the area was a bit unreliable but not the hotel’s fault. Every available amenity like laundry and luggage holding was an extra 5 Euro which felt a bit excessive (5 for wash, another 5 to dry)."

Reviewed on 13 September 2025

Hotel Firenze 2000
See all 473 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Santo Spirito

Brancacci Chapel which includes a church or cathedral and heritage architecture

San Frediano

San Frediano is popular for its stunning river views, and if you're looking for more to see and do, you might think about a trip to Piazza Santo Spirito or Santo Spirito Basilica.

San Frediano
Arcetri which includes a river or creek, a sunset and a bridge

Oltrarno

4.5/5(529 area reviews)

South of the River Arno, this quarter boasts part of Florence's historic center, featuring notable sites like Santo Spirito di Firenze, Palazzo Pitti, Belvedere, and Piazzale Michelangelo.

Oltrarno
Santa Maria Novella which includes heritage architecture, a church or cathedral and street scenes

Santa Maria Novella

4.5/5(1,057 area reviews)

Enjoy the popular shops in Santa Maria Novella. The New Florence Opera House is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Santa Maria Novella
Uffizi Gallery which includes street scenes as well as a large group of people

San Giovanni

If you're spending some time in San Giovanni, Uffizi Gallery and Cathedral of Santa Maria del Fiore are top sights worth seeing.

San Giovanni
Duomo featuring heritage architecture and street scenes as well as a small group of people

Duomo

5/5(2,214 area reviews)

Cathedral of Santa Maria del Fiore and Uffizi Gallery are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

Duomo
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

Known for its fascinating museums, stunning cathedral, and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Cathedral of Santa Maria del Fiore and Uffizi Gallery are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

Historic Centre of Florence

Santo Spirito

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