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Our top choices for Southeast Missouri hotels with a casino
The Farmstead Hotel
Caruthersville
8.8 out of 10, Excellent, (461)
"Clean rooms and really comfortable beds!"
Andrea
The price is AED 314
AED 357 total
includes taxes & fees
11 Dec - 12 Dec
The Riverview
Cape Girardeau
9.4 out of 10, Exceptional, (466)
"Place was nice and safe"
ryan
The price is AED 322
AED 363 total
includes taxes & fees
17 Dec - 18 Dec
Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
Deborah
The price is AED 426
AED 483 total
includes taxes & fees
21 Dec - 22 Dec
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
8.8 out of 10, Excellent, (661)
"Great place "
GUY
The price is AED 287
AED 311 total
includes taxes & fees
4 Jan - 5 January 2026
Baymont by Wyndham Festus
Festus
6.8 out of 10, (919)
"Room was clean and comfortable for an overnight stay"
Jack
The price is AED 297
AED 340 total
includes taxes & fees
7 Jan - 8 January 2026
Rockwood Inn
Cape Girardeau
10.0 out of 10, Exceptional, (18)
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
Vanessa
The price is AED 519
AED 585 total
includes taxes & fees
11 Dec - 12 Dec
Century Casino & Hotel Caruthersville
Caruthersville
8.6 out of 10, Excellent, (103)
"Room was clean staff was really nice"
Toni
The price is AED 437
AED 497 total
includes taxes & fees
11 Dec - 12 Dec
Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
Tracy H.
The price is AED 551
AED 900 total
includes taxes & fees
11 Dec - 12 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Missouri Hotel Reviews
Candlewood Suites Cape Girardeau by IHG
10/10 Excellent
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More Accommodation Types in Southeast Missouri
Hotels near popular Southeast Missouri Attractions
- Hotels near Southeast Missouri State University
- Hotels near Johnson's Shut-ins State Park
- Hotels near Ozark National Scenic Riverways
- Hotels near Elephant Rocks State Park
- Hotels near Century Casino Caruthersville
- Hotels near Isle Casino Cape Girardeau
- Hotels near Lake Wappapello
- Hotels near Echo Bluff State Park
- Hotels near Sainte Genevieve Winery
- Hotels near Taum Sauk Mountain State Park
Southeast Missouri Hotels by Star Rating
Explore more hotels
- Courtyard by Marriott Cape Girardeau Downtown
- Drury Inn & Suites Sikeston, MO
- Drury Inn & Suites Jackson MO
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Candlewood Suites Cape Girardeau by IHG
- Drury Inn & Suites Poplar Bluff
- Pear Tree Inn Cape Girardeau West
- Baymont by Wyndham Festus
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- Super 8 by Wyndham Farmington
- Hampton Inn Cape Girardeau I 55 East
- Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
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- Holiday Inn Express & Suites Perryville by IHG
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