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Find Luxury Hotels in Southeast Missouri, MO

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Pick from 12 Southeast Missouri Luxury Hotels and compare room rates, reviews, and availability. Most hotels are fully refundable.

Historical Kage House
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
10.0 out of 10, Exceptional, (202)
"beautiful place. great location. recommend to anyone"
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Pool
Drury Inn & Suites Sikeston, MO
3.0 star property
9.4 out of 10, Exceptional, (1000)
"Convenient location and newer facility compared to other area options."
The price is AED 364
AED 413 total
includes taxes & fees
9 Jun - 10 Jun
Drury Inn & Suites Sikeston, MO
Exterior
Drury Inn & Suites Cape Girardeau
3.0 star property
9.4 out of 10, Exceptional, (786)
"Everyone was very friendly and the breakfast provided was amazing!! "
The price is AED 397
AED 447 total
includes taxes & fees
28 May - 29 May
Drury Inn & Suites Cape Girardeau
Exterior
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
9.0 out of 10, Wonderful, (1002)
"Except for the bugs in my room, everything was good,"
The price is AED 231
AED 261 total
includes taxes & fees
27 May - 28 May
Pear Tree Inn Cape Girardeau Near the Medical Center
Front of property
Motel 6 Poplar Bluff, MO
2.0 star property
8.0 out of 10, Very Good, (1001)
"Nice place to stay. Good for those on a budget. Basic room. Everything worked. Fairly new property. Have stayed at property several times. Easy access to main roads"
The price is AED 290
AED 306 total
includes taxes & fees
27 May - 28 May
Motel 6 Poplar Bluff, MO
Exterior
Comfort Inn Festus - St Louis South
2.5 star property
8.0 out of 10, Very Good, (688)
"Clean and affordable "
The price is AED 314
AED 358 total
includes taxes & fees
27 May - 28 May
Comfort Inn Festus - St Louis South
Room
Days Inn and Suites by Wyndham Sikeston
2.0 star property
7.0 out of 10, Good, (1003)
"Great value and super quiet. "
The price is AED 250
AED 278 total
includes taxes & fees
27 May - 28 May
Days Inn and Suites by Wyndham Sikeston
Exterior
Quality Inn Festus
3.0 star property
7.0 out of 10, Good, (870)
"We explicitly look for places with hotel bars and they listed as having one and they haven’t had one in years according to the clerk - very disappointing "
Quality Inn Festus
Exterior
Quality Inn
2.5 star property
7.0 out of 10, Good, (465)
"Na"
The price is AED 246
AED 278 total
includes taxes & fees
27 May - 28 May
Quality Inn
Exterior
Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
6.6 out of 10, (464)
"Only stopped for a quick layover. Room was fine, bathroom was in pretty rough shape. Everything in the area seems new, hotel needs a remodel."
The price is AED 228
AED 253 total
includes taxes & fees
29 May - 30 May
Super 8 by Wyndham Poplar Bluff Missouri
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent reviews of Southeast Missouri hotels
Expedia verified reviews

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

5/5 Excellent
"Great value and super quiet. "
A verified traveler stayed at Days Inn and Suites by Wyndham Sikeston
Posted 12 hours ago
Days Inn and Suites by Wyndham Sikeston