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Find Business Hotels in Southeast Missouri, MO
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Pick from 50 Southeast Missouri Business Hotels and compare room rates, reviews, and availability. Most hotels are fully refundable.
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
9.6 out of 10, Exceptional, (1002)
The price is AED 430
AED 480 total
includes taxes & fees
29 May - 30 May
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO
9.6 out of 10, Exceptional, (960)
The price is AED 397
AED 419 total
includes taxes & fees
28 May - 29 May
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
9.4 out of 10, Exceptional, (1002)
The price is AED 347
AED 397 total
includes taxes & fees
28 May - 29 May
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
9.4 out of 10, Exceptional, (786)
The price is AED 397
AED 447 total
includes taxes & fees
28 May - 29 May
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
9.0 out of 10, Wonderful, (1004)
The price is AED 241
AED 272 total
includes taxes & fees
9 Jun - 10 Jun
Auburn Place Hotel And Suites
Auburn Place Hotel And Suites
8.8 out of 10, Excellent, (1004)
The price is AED 290
AED 321 total
includes taxes & fees
26 May - 27 May
Microtel Inn & Suites by Wyndham Sainte Genevieve
Microtel Inn & Suites by Wyndham Sainte Genevieve
8.8 out of 10, Excellent, (492)
The price is AED 294
AED 328 total
includes taxes & fees
2 Jun - 3 Jun
Holiday Inn Poplar Bluff, an IHG Hotel
Holiday Inn Poplar Bluff, an IHG Hotel
8.8 out of 10, Excellent, (566)
The price is AED 415
AED 462 total
includes taxes & fees
27 May - 28 May
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
8.6 out of 10, Excellent, (343)
The price is AED 474
AED 537 total
includes taxes & fees
2 Jun - 3 Jun
Best Western Plus Sikeston
Best Western Plus Sikeston
8.4 out of 10, Very Good, (1002)
The price is AED 370
AED 413 total
includes taxes & fees
26 May - 27 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent reviews of Southeast Missouri hotelsExpedia verified reviews
5/5 Excellent
"Great value and super quiet. "
A verified traveler stayed at Days Inn and Suites by Wyndham Sikeston
Posted 19 hours ago
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- Hotels with smoking rooms (9)
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- Pet-friendly Hotels (48)
- Resorts & Hotels with Spas (14)
- Romantic Hotels (5)
- Shopping Hotels (29)
- Ski Hotels (1)
- Winery Hotels (7)
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Hotels near popular Southeast Missouri Attractions
- Hotels near Johnson's Shut-ins State Park
- Hotels near Elephant Rocks State Park
- Hotels near Echo Bluff State Park
- Hotels near Lake Wappapello
- Hotels near Southeast Missouri State University
- Hotels near Ozark National Scenic Riverways
- Hotels near Big Spring
- Hotels near Century Casino Caruthersville
- Hotels near Alley Spring & Mill
- Hotels near Isle Casino Cape Girardeau
Southeast Missouri Hotels by Star Rating
Explore more hotels
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Silo Farm Haus- located in the heart of wine country!
- Pear Tree Inn Sikeston
- Super 8 by Wyndham Farmington
- Candlewood Suites Cape Girardeau, an IHG Hotel
- Fairfield Inn & Suites by Marriott Poplar Bluff
- Comfort Inn Festus - St Louis South
- Quality Inn
- Super 8 by Wyndham Perryville
- Courtyard by Marriott Cape Girardeau Downtown
- The Farmstead Hotel
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Best Western Plus Sikeston
- Holiday Inn Express & Suites Perryville, an IHG Hotel
- Drury Inn & Suites Hayti Caruthersville
- Travel Inn & Suites
- Hampton Inn Poplar Bluff
- New Orleans Inn Portageville
- Drury Inn & Suites Poplar Bluff
- Comfort Suites Jackson-Cape Girardeau