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- Resorts & Hotels with Spas (14)
- Romantic Hotels (5)
- Shopping Hotels (29)
- Ski Hotels (1)
- Winery Hotels (7)
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Hotels near popular Southeast Missouri Attractions
- Hotels near Johnson's Shut-ins State Park
- Hotels near Elephant Rocks State Park
- Hotels near Echo Bluff State Park
- Hotels near Ozark National Scenic Riverways
- Hotels near Southeast Missouri State University
- Hotels near Lake Wappapello
- Hotels near Big Spring
- Hotels near Alley Spring & Mill
- Hotels near Current River State Park
- Hotels near Century Casino Caruthersville
Southeast Missouri Hotels by Star Rating
Explore more hotels
- Super 8 by Wyndham Farmington
- Silo Farm Haus- located in the heart of wine country!
- Drury Inn & Suites Cape Girardeau
- Pear Tree Inn Sikeston
- Courtyard by Marriott Cape Girardeau Downtown
- Best Western Plus Sikeston
- Candlewood Suites Cape Girardeau, an IHG Hotel
- Comfort Inn Festus - St Louis South
- New Orleans Inn Portageville
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Town House Inn
- Quality Inn
- Drury Inn & Suites Poplar Bluff
- Fairfield Inn & Suites by Marriott Poplar Bluff
- Comfort Suites Jackson-Cape Girardeau
- The Farmstead Hotel
- Hampton Inn Poplar Bluff
- Holiday Inn Express & Suites Perryville, an IHG Hotel
- Super 8 by Wyndham Perryville
- Drury Inn & Suites Hayti Caruthersville