Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from AED 221

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Our top choices for Southeast Missouri hotels

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (856)
"The rooms were very clean and well maintained and th e staff was great and the young lady who checked us in was awsome at her job she helped me get the smart tv workin and has a very professional and respectfull through the hole stay we thank this is the nicest hotel i ve stayed at by far andcwill be back "
United States
Terry
The price is AED 382
AED 432 total
includes taxes & fees
9 Jan - 10 January 2026
Fairfield Inn & Suites by Marriott Poplar Bluff

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
Located just off the highway near Sikeston dining and shopping, this hotel offers both indoor and outdoor pools for year-round swimming. Guests praise the peaceful atmosphere, helpful staff, and complimentary breakfast, parking, and WiFi.

"This our favorite place to stop for a good night sleep. "
United States
Eileen
The price is AED 331
AED 380 total
includes taxes & fees
29 Dec - 30 Dec
Drury Inn & Suites Sikeston, MO

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (706)
Italian cuisine awaits at Castellos restaurant in this peaceful hotel. Take a refreshing swim in the indoor pool, work out in the fitness center, or explore nearby North Main Street Historic District. Guests love the helpful staff.

"Amazing place"
United States
Mladen
The price is AED 386
AED 436 total
includes taxes & fees
2 Jan - 3 January 2026
Holiday Inn Poplar Bluff by IHG

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
Explore Shawnee National Forest from this Cape Girardeau hotel offering complimentary breakfast, WiFi, and parking. Enjoy the indoor pool and hot tub after a day out, or dine at The Southerner restaurant. Each room includes handy refrigerators and microwaves.

"Great place and staff, very accommodating!"
United States
Megan
The price is AED 331
AED 373 total
includes taxes & fees
28 Dec - 29 Dec
Drury Plaza Hotel Cape Girardeau Conference Center

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (463)
Surrounded by tranquil environments for rest and relaxation, this Caruthersville hotel offers gaming excitement at the onsite casino. Clean rooms and helpful staff earn praise from guests, while Century Casino and the public library wait just minutes away.

"Nice place "
United States
Debbie
The price is AED 314
AED 357 total
includes taxes & fees
26 Dec - 27 Dec
The Farmstead Hotel

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1009)
Located in Sikeston, this hotel offers an indoor pool for relaxing swims after a day of exploring. Near Central Park and the Sikeston Depot Museum, guests praise the delicious free breakfast and attentive service.

"Great stay, everything was clean and comfortable. "
United States
Charles
The price is AED 278
AED 317 total
includes taxes & fees
28 Dec - 29 Dec
Best Western Plus Sikeston

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (797)
Located near North Main Street Historic District, this welcoming hotel offers an indoor pool for year-round swimming and a well-equipped fitness center. Guests love the complimentary breakfast, free WiFi and parking. The helpful staff ensures a comfortable stay just minutes from local attractions.

"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is AED 415
AED 464 total
includes taxes & fees
24 Jan - 25 January 2026
Hampton Inn Poplar Bluff

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (722)
Enjoy tranquil accommodations at this welcoming Sikeston hotel where helpful staff receive consistent praise. Located near Central Park and Sikeston Depot Museum, guests appreciate the quiet atmosphere, clean rooms, and daily continental breakfast.

"Room was good as usual. This is 4th stay over past 5 years. Only issue I had on this stay was the orange juice from breakfast options. "
United States
Todd
The price is AED 204
AED 232 total
includes taxes & fees
25 Dec - 26 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1000)
Wake up to complimentary breakfast at this quiet retreat near Shawnee National Forest. Guests love the peaceful atmosphere, helpful staff, and convenient location close to Cape Splash Family Aquatic Center. Free WiFi and parking enhance the overall value.

"Great stay"
United States
Heather
The price is AED 257
AED 290 total
includes taxes & fees
28 Dec - 29 Dec
Pear Tree Inn Cape Girardeau West

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (543)
Modern accommodations near Perryville Country Club featuring an indoor pool for morning swims and a 24-hour fitness center. Enjoy complimentary breakfast, WiFi and parking while exploring nearby Saint Marys Lake. Travelers praise the clean rooms and helpful staff.

"lean, updated rooms, friendly staff and great breakfast."
United States
Linda
The price is AED 320
AED 366 total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Express & Suites Perryville by IHG

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (333)
Set in scenic Mountain View, this welcoming hotel offers free breakfast, WiFi, and parking. Enjoy 24-hour fitness facilities or explore nearby hiking trails. Guests consistently praise the helpful staff and immaculate rooms.

"Staff was very friendly."
United States
Joyce
The price is AED 350
AED 380 total
includes taxes & fees
25 Dec - 26 Dec
Honeysuckle Inn - Mountain View

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1010)
This quiet retreat offers an indoor pool for morning swims and a relaxing hot tub to end your day. Clean rooms provide a peaceful atmosphere near Litz Park and Lazy L Safari Park, with free breakfast, WiFi, and parking to enhance your stay.

"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is AED 305
AED 322 total
includes taxes & fees
28 Dec - 29 Dec
Drury Inn & Suites Jackson MO

Echo Bluff State Park

Echo Bluff State Park
2.5 star property
Eminence
9.6 out of 10, Exceptional, (217)
Immersed in nature at Echo Bluff State Park, this hotel offers hiking and mountain biking trails for outdoor enthusiasts. Free WiFi and parking add convenience, while Current River State Park awaits nearby exploration.

"The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)"
United States
Joanne
The price is AED 549
AED 580 total
includes taxes & fees
31 Dec - 1 January 2026
Echo Bluff State Park

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (968)
Discover peaceful stays near North Main Street Historic District. This hotel offers dual pools, free breakfast, and complimentary WiFi. After exploring nearby Margaret Harwell Art Museum, return to spacious rooms where the helpful staff ensures comfort.

"Nice room helpful staff. "
United States
Deborah
The price is AED 389
AED 440 total
includes taxes & fees
20 Jan - 21 January 2026
Drury Inn & Suites Poplar Bluff

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very Good, (1000)
Enjoy a welcoming stay at this motel with free WiFi and parking near North Main Street Historic District. Staff receives praise for helpfulness, while convenient access to Margaret Harwell Art Museum enriches your Poplar Bluff experience.

"It was a nice stay."
United States
Rebecca
The price is AED 279
AED 294 total
includes taxes & fees
25 Dec - 26 Dec
Motel 6 Poplar Bluff, MO

Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South
2.5 star property
Festus
7.8 out of 10, Good, (911)
Peaceful hotel close to Sunset Park offers free breakfast, WiFi, and parking. Guests love the minimal noise levels and helpful staff. The fitness center provides workout options while being just a 10-minute drive from Mississippi River attractions.

"Vary clean"
United States
George
The price is AED 278
AED 325 total
includes taxes & fees
26 Dec - 27 Dec
Comfort Inn Festus - St Louis South

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very Good, (1001)
This Farmington hotel offers easy highway access near local restaurants in a quiet setting. Travelers appreciate the comfortable beds, helpful staff, and clean rooms. Enjoy the seasonal pool, 24-hour fitness center, and complimentary breakfast before exploring nearby parks.

"Room was clean , staff was friendly !"
United States
Sally
The price is AED 194
AED 221 total
includes taxes & fees
2 Jan - 3 January 2026
Baymont Inn and Suites by Wyndham Farmington, MO

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very Good, (892)
Enjoy a peaceful retreat at this Festus hotel offering complimentary breakfast, WiFi, and parking. The fitness center provides workout options while the helpful staff ensures a pleasant stay. Located conveniently near Jorkerst Memorial Park and Sunset Park.

"Breakfast was great! Location right off interstate was perfect. The property is a little old."
United States
Mindy
The price is AED 340
AED 389 total
includes taxes & fees
25 Dec - 26 Dec
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1004)
This peaceful hotel offers a quiet atmosphere just minutes from Shawnee National Forest and Cape Splash Family Aquatic Center. Nearby restaurants and stores enhance convenience while helpful staff ensure a comfortable stay with free WiFi and daily housekeeping.

"Nice place for a stay at a reasonable price."
United States
Arthur
The price is AED 257
AED 290 total
includes taxes & fees
28 Dec - 29 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center

Fort Davidson Hotel

Fort Davidson Hotel
2.5 star property
Ironton
9.2 out of 10, Wonderful, (174)
Located minutes from the Fort Davidson State Historic Site, this Ironton hotel offers an outdoor pool and complimentary train station pickup. Enjoy free WiFi, parking, and easy access to the Battle of Pilot Knob Museum from this comfortable base.

"Friendly staff, spacious room, nice pool!!"
United States
SHARON
The price is AED 441
AED 481 total
includes taxes & fees
25 Dec - 26 Dec
Fort Davidson Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Vacation Rentals in Southeast Missouri

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Stay near popular Southeast Missouri attractions

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

More cheap stays in Southeast Missouri

Hotels in Southeast Missouri with star-rating

Find out more about Southeast Missouri

Top reasons to visit Southeast Missouri

  • Outdoor Adventures: Southeast Missouri is perfect for outdoor enthusiasts, offering hiking, scenic retreats, and recreational activities.
  • Family-Friendly Experiences: The region provides numerous activities suitable for families, ensuring fun for all ages.
  • Cultural Attractions: Explore historic civic buildings and nearby sites, including Southeast Missouri State University.
  • Inviting Parks: Enjoy picturesque urban and state parks for leisurely strolls and nature exploration.
  • Diverse Accommodations: Choose from a range of lodging options, from cozy motels to well-equipped hotels to fit any traveler’s needs.

Find great hotels near Southeast Missouri

Explore the diverse hotel accommodations in Southeast Missouri, where options range from cozy motels to well-equipped hotels tailored for business travelers and adventure seekers alike. Whether you're looking for pet-friendly places or the best-reviewed stays, this region offers a variety of choices to suit every traveler's needs. Discover the perfect lodging to make your visit memorable, conveniently located near popular attractions and activities.

  • Madison Inn Lodge: Ideal for pet lovers and business travelers, Madison Inn Lodge is a welcoming motel located 25.7km from Southeast Missouri. This lodge embraces a pet-friendly atmosphere, allowing guests to bring their furry companions along for the adventure. Offering essential amenities like complimentary Wi-Fi and comfortable accommodations, it ensures a hassle-free stay. The property also features a welcoming environment for service animals, making it a perfect choice for those traveling for work or leisure with pets in tow.
  • Shepherd Mountain Inn: Located 33.8km from Southeast Missouri, Shepherd Mountain Inn stands out as a reliable choice for business travelers. This hotel provides a focused and comfortable environment, making it easy for guests to unwind or catch up on work. With modern amenities and convenient services, it caters to the needs of professionals seeking a productive stay. The inn's strategic location allows easy access to nearby business hubs and local attractions, ensuring that guests can balance work and leisure seamlessly.
  • Alpaca Farm Stay: For those yearning for adventure or a romantic getaway, Alpaca Farm Stay is a charming lodge just 12.9km away from Southeast Missouri. Nestled in nature, it offers various outdoor activities including mountain biking, kayaking, and hiking, catering to families and thrill-seekers alike. With amenities designed for children, such as a shared playground, it’s perfect for family vacations. Guests can also enjoy stunning views of the lake and mountains while indulging in romance packages, creating unforgettable memories amidst beautiful surroundings.

Where to stay near Southeast Missouri

Southeast Missouri offers an inviting blend of outdoor adventures and family-friendly experiences. Enjoy leisurely strolls through picturesque parks, or embark on scenic retreats to explore lush landscapes. With friendly locals and convenient access to attractions, visitors can indulge in recreational activities suitable for all ages. Don’t miss the chance to soak in the region's vibrant atmosphere during its wettest month, making it an unforgettable getaway for nature lovers and families alike.

  • Annapolis: Located 22.5km from Southeast Missouri, Annapolis is a charming city that attracts visitors year-round, especially during the warmer months of June to July and September. Known for its outdoor adventures and scenic beauty, this city offers a variety of recreational areas and an entertainment arena. Nature lovers will appreciate the proximity to a national state park, rivers, and picturesque parks, making Annapolis an ideal spot for those seeking adventure and outdoor experiences.
  • Central Fredericktown: Just 16.1km from Southeast Missouri, Central Fredericktown is a quaint village that draws family-oriented travelers looking for a city-themed experience. The peak travel times from June to August make it a lively destination during the summer months. Visitors can enjoy educational venues, shopping mall centers, and urban parks. The local history museum provides a glimpse into the region's past, while the various parks offer a relaxing escape for families and outdoor enthusiasts alike.
  • Des Arc: A mere 17.7km from Southeast Missouri, Des Arc is a vibrant city known for its seasonal influx of visitors, peaking from June to August. This city is perfect for those who enjoy outdoor activities and stunning scenery. Des Arc features an array of recreational areas, a water park, and an entertainment arena, ensuring fun for all ages. Outdoor enthusiasts will love the nearby national state park, lake, and rivers, making it a fantastic destination for adventure seekers and nature lovers.

Things to do near Southeast Missouri

Southeast Missouri is perfect for outdoor enthusiasts and adventure seekers, offering a variety of activities. Visitors can enjoy campus tours, outdoor sports tournaments, and brewery tours. The region also boasts recreational areas and educational experiences, making it an ideal destination for those looking to explore nature and engage in fun activities. Whether you're interested in sports or learning, there's something for everyone in Southeast Missouri.

Shopping

Experience shopping at Red's Flea Market, located 41.8km from Southeast Missouri, where you'll find a variety of unique gifts and treasures. Additionally, visit the Farmington Mineral Area Shopping Center, 48.3km away, offering a mix of family-friendly entertainment, shops, and dining options.

Recreation

Crane Lake Recreation Area offers a peaceful retreat with serene surroundings, perfect for relaxation and rejuvenation. Arcadia Valley Golf Club provides an invigorating outdoor experience with its scenic golf course. Silver Mine Recreation Area combines wellness and nature, featuring tranquil trails and beautiful landscapes for ultimate relaxation.

Adventure

Shepherd Mountain Bike Park and Hiking Trails offers thrilling outdoor adventures only 33.8km from Southeast Missouri. Experience scenic biking paths and hiking trails that wind through lush landscapes, perfect for both adrenaline seekers and nature lovers looking to immerse themselves in the beautiful surroundings.

Nightlife

Southeast Missouri's nightlife offers a mix of cozy bars and lively venues. Enjoy live music at The Blue Note in Columbia or sip craft beers at a local brewery. For dancing, head to The Parlor in Cape Girardeau, where vibrant crowds and energetic beats create an unforgettable atmosphere.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Southeast Missouri

To save money during your trip to Southeast Missouri, plan to visit between November and January, when accommodation prices are lower. Tuesdays are the cheapest days to book, while Saturdays tend to be the most expensive. Use Expedia's search tool to find budget-friendly hotels by sorting prices and applying filters for eco-certified options. Additionally, consider booking package deals that combine flights, hotels, and activities for extra savings. Take advantage of free local attractions and affordable public transport to explore the area without overspending.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Southeast Missouri are November to January, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Southeast Missouri is Tuesday. The most expensive day to stay around Southeast Missouri is Saturday.
  • Find cheap hotels on Expedia: Expedia's search tool enables you to set your budget, choose your desired location, and much more. You can organize your results to display prices from lowest to highest, ensuring you see the most affordable hotels first. Additionally, you have the option to narrow down your choices by hotel type. For instance, by selecting the Eco-certified filter, you'll find a selection of sustainable and environmentally-friendly hotels available for booking.
  • Consider bundling your trip: You can save money by combining your hotel reservations in Southeast Missouri with your flights and activities by choosing an Expedia package.

Find the best attractions near Southeast Missouri

Southeast Missouri offers a fantastic blend of outdoor adventures and scenic beauty, making it an ideal destination for families and nature lovers. Visitors can explore urban parks, state parks, and historic civic buildings. Notable attractions include nearby sites and Southeast Missouri State University, providing a mix of educational and recreational experiences. Whether you're hiking, sightseeing, or enjoying family-friendly activities, Southeast Missouri has something for everyone.

  • Walnut Hollow Lake: Nestled 20.9km away, Walnut Hollow Lake offers a serene escape with its picturesque beaches and stunning scenery. Ideal for a romantic day out or a peaceful retreat, this lake is perfect for swimming, picnicking, or simply enjoying the natural beauty.
  • K Bridge Recreation Area: Located 27.4km from Southeast Missouri, this urban park is a family-friendly destination featuring open spaces for picnics, walking trails, and playgrounds. It’s a great spot to unwind and enjoy the city vibes while spending quality time with loved ones.
  • Millstream Gardens Conservation Area: Just 24.1km away, this conservation area is rich in history and adventure. With friendly locals and relaxing trails, it’s ideal for families seeking outdoor fun, making it a perfect place to connect with nature and explore.

Best time to go to Southeast Missouri

The best time to visit Southeast Missouri can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Southeast Missouri falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature around Southeast Missouri falls in January, visitor numbers are slightly low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January34.9°F (1.6°C)Light RainMostly SunnySlightly LowSlightly Low
February38.1°F (3.4000000000000004°C)Light RainMostly SunnySlightly LowAverage
March48.0°F (8.9°C)Light RainMostly SunnyAverageAverage
April57.6°F (14.2°C)Light RainMostly SunnyAverageSlightly High
May67.3°F (19.6°C)Light RainMostly SunnyAverageAverage
June76.5°F (24.700000000000003°C)Light RainMostly SunnySlightly HighSlightly High
July79.2°F (26.200000000000003°C)Light RainMostly SunnySlightly HighAverage
August77.2°F (25.1°C)Light RainMostly SunnySlightly HighSlightly High
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October59.9°F (15.5°C)Light RainMostly SunnyAverageAverage
November47.5°F (8.6°C)Light RainMostly SunnyAverageSlightly Low
December39.4°F (4.1000000000000005°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Southeast Missouri

When visiting Southeast Missouri, you can fly into several major airports. St. Louis Lambert International Airport (STL) is located 154.5km away, with nearby hotels like The Ritz-Carlton and Ameristar Casino Resort, both about 11.3km from the airport. Fort Leonard Wood Regional Airport (TBN) is also 154.5km away, offering accommodations such as the Z Loft Extended Stay Hotel, just 9.7km from the airport. Additionally, Barkley Regional Airport (PAH) in Paducah, KY is 152.9km away, with options like The Respite Bed and Breakfast located 14.5km from the airport. Each of these airports provides accessible transport to nearby hotels for a convenient stay.

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